Integrin-mediated cell adhesion (WP951)

Pan troglodytes

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]
last edited


Thomas Kelder and Daniela Digles

Cited In

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Pathway Ontology: integrin mediated signaling pathway


Label Type Compact Identifier Comment
CDC42 GeneProduct ncbigene:456609 CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1 GeneProduct ncbigene:457351 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3 GeneProduct ncbigene:450176 SHC3; neuronal Sh
BRAF GeneProduct ncbigene:463781 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1 GeneProduct ncbigene:460182 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK7 GeneProduct ncbigene:454499 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2 GeneProduct ncbigene:742591 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
ARHGEF7 GeneProduct ncbigene:452673 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC2 GeneProduct ncbigene:742575 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
VAV3 GeneProduct ncbigene:457076 VAV3; vav 3 oncogene
ROCK2 GeneProduct ncbigene:470307 ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1 GeneProduct ncbigene:455326 ROCK1; Rho-associated coiled-coil containing protein kinase
SORBS1 GeneProduct ncbigene:450628 SH3D5; SH3-domain protein 5 (ponsin
SOS1 GeneProduct ncbigene:459171 SOS1; son of sevenless homolog 1 (Drosophila)
GIT2 GeneProduct ncbigene:452227 GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2 GeneProduct ncbigene:455855 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
CAV1 GeneProduct ncbigene:463670 CAV1; caveolin 1 caveolae protein 22kD
CAV2 GeneProduct ncbigene:494183 CAV2; caveolin 2
CAV3 GeneProduct ncbigene:738786 CAV3; caveolin 3
FYN GeneProduct ncbigene:462944 FYN; FYN oncogene related to SRC FGR YES [EC:]
GRB2 GeneProduct ncbigene:737245 GRB2; growth factor receptor-bound protein 2
SEPP1 GeneProduct ncbigene:461897 SEPP1; selenoprotein P plasma
HRAS GeneProduct ncbigene:466302
PTK2 GeneProduct ncbigene:464422 PTK2; PTK2 protein tyrosine kinase 2 [EC:
PTK2 GeneProduct ncbigene:464422 PTK2; PTK2 protein tyrosine kinase 2 [EC:
RHO GeneProduct ncbigene:460685 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK GeneProduct ncbigene:453745 CSK; c-src tyrosine kinase [EC:]
BCAR1 GeneProduct ncbigene:454246 BCAR1; breast cancer anti-estrogen resistance 1
SRC GeneProduct ncbigene:458229 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
AKT1 GeneProduct ncbigene:740898 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:456035 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN3 GeneProduct ncbigene:453363 CAPN3; calpain 3 (p94) [EC:]
CAPN5 GeneProduct ncbigene:451438 CAPN5; calpain
CAPN7 GeneProduct ncbigene:460202 CAPN7; calpain 7 [EC:
CAPN9 GeneProduct ncbigene:457812 CAPN9; calpain 9 (nCL-4) [EC:
CAPN11 GeneProduct ncbigene:462727 CAPN11; calpain 11 [EC:]
CAPN6 GeneProduct ncbigene:465810 CAPN6; calpain 6 [EC:]
PAK2 GeneProduct ncbigene:460965 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3 GeneProduct ncbigene:450118 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
MAP2K3 GeneProduct ncbigene:454515 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5 GeneProduct ncbigene:453532 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6 GeneProduct ncbigene:468310 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
AKT3 GeneProduct ncbigene:735718 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1 GeneProduct ncbigene:739420 DOCK1; dedicator of cyto-kinesis
CRK GeneProduct ncbigene:747142 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
RAPGEF1 GeneProduct ncbigene:464812 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A GeneProduct ncbigene:469408 RAP1A; RAP1A member of RAS oncogene family
RAP1B GeneProduct ncbigene:452065 RAP1B; RAP1B member of RAS oncogene family
MAPK1 GeneProduct ncbigene:458680 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6 GeneProduct ncbigene:453439 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1 GeneProduct ncbigene:450188 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:456390 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:451317 CAPN1; calpain 1 (mu/I) large subunit [EC:]
ITGA2 GeneProduct ncbigene:471550
ITGA3 GeneProduct ncbigene:455111
ITGA4 GeneProduct ncbigene:470596
ITGA5 GeneProduct ncbigene:451958
ITGA6 GeneProduct ncbigene:459742
ITGA8 GeneProduct ncbigene:450323
ITGA9 GeneProduct ncbigene:470789
ITGA10 GeneProduct ncbigene:457982
ITGA11 GeneProduct ncbigene:453537
ITGA2B GeneProduct ncbigene:454730
ITGAD GeneProduct ncbigene:468103
ITGAL GeneProduct ncbigene:454045
ITGAM GeneProduct ncbigene:454069
ITGAV GeneProduct ncbigene:459807
ITGAX GeneProduct ncbigene:454070
ITGB1 GeneProduct ncbigene:450396
ITGB2 GeneProduct ncbigene:458607
ITGB3 GeneProduct ncbigene:468295
ITGB4 GeneProduct ncbigene:454887
ITGB5 GeneProduct ncbigene:460646
ITGB6 GeneProduct ncbigene:459683
ITGB7 GeneProduct ncbigene:451934
ITGB8 GeneProduct ncbigene:463282
SRC GeneProduct ncbigene:458229 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
VCL GeneProduct ncbigene:450531 VCL; vinculin
TNS1 GeneProduct ncbigene:459934 TNS; tensi
MAPK10 GeneProduct ncbigene:461358
PXN GeneProduct ncbigene:452303 PXN; paxillin
ILK GeneProduct ncbigene:748941 ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1 GeneProduct ncbigene:451439 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP GeneProduct ncbigene:468919 VASP; vasodilator-stimulated phosphoprotein
ITGA7 GeneProduct ncbigene:451967
ITGA1 GeneProduct ncbigene:461880


  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia