Integrin-mediated cell adhesion (WP951)
Pan troglodytes
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]
Authors
Thomas Kelder and Daniela DiglesCited In
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Organism
Communities
Annotations
Pathway Ontology: integrin mediated signaling pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| CDC42 | GeneProduct | ncbigene:456609 | CDC42; cell division cycle 42 (GTP binding protein 25kD) |
| SHC1 | GeneProduct | ncbigene:457351 | SHC1; SHC (Src homology 2 domain containing) transforming protein 1 |
| SHC3 | GeneProduct | ncbigene:450176 | SHC3; neuronal Sh |
| BRAF | GeneProduct | ncbigene:463781 | BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-] |
| RAF1 | GeneProduct | ncbigene:460182 | RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-] |
| MAPK7 | GeneProduct | ncbigene:454499 | MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.- |
| MYLK2 | GeneProduct | ncbigene:742591 | MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117 |
| ARHGEF7 | GeneProduct | ncbigene:452673 | ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7 |
| RAC2 | GeneProduct | ncbigene:742575 | RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2) |
| VAV3 | GeneProduct | ncbigene:457076 | VAV3; vav 3 oncogene |
| ROCK2 | GeneProduct | ncbigene:470307 | ROCK2; Rho-associated coiled-coil containing protein kinase |
| ROCK1 | GeneProduct | ncbigene:455326 | ROCK1; Rho-associated coiled-coil containing protein kinase |
| SORBS1 | GeneProduct | ncbigene:450628 | SH3D5; SH3-domain protein 5 (ponsin |
| SOS1 | GeneProduct | ncbigene:459171 | SOS1; son of sevenless homolog 1 (Drosophila) |
| GIT2 | GeneProduct | ncbigene:452227 | GIT2; G protein-coupled receptor kinase-interactor 2 |
| PIK3R2 | GeneProduct | ncbigene:455855 | PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta) |
| CAV1 | GeneProduct | ncbigene:463670 | CAV1; caveolin 1 caveolae protein 22kD |
| CAV2 | GeneProduct | ncbigene:494183 | CAV2; caveolin 2 |
| CAV3 | GeneProduct | ncbigene:738786 | CAV3; caveolin 3 |
| FYN | GeneProduct | ncbigene:462944 | FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112] |
| GRB2 | GeneProduct | ncbigene:737245 | GRB2; growth factor receptor-bound protein 2 |
| SEPP1 | GeneProduct | ncbigene:461897 | SEPP1; selenoprotein P plasma |
| HRAS | GeneProduct | ncbigene:466302 | |
| PTK2 | GeneProduct | ncbigene:464422 | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 |
| PTK2 | GeneProduct | ncbigene:464422 | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 |
| RHO | GeneProduct | ncbigene:460685 | RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant) |
| CSK | GeneProduct | ncbigene:453745 | CSK; c-src tyrosine kinase [EC:2.7.1.112] |
| BCAR1 | GeneProduct | ncbigene:454246 | BCAR1; breast cancer anti-estrogen resistance 1 |
| SRC | GeneProduct | ncbigene:458229 | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
| AKT1 | GeneProduct | ncbigene:740898 | AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-] |
| AKT2 | GeneProduct | ncbigene:456035 | AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-] |
| CAPN3 | GeneProduct | ncbigene:453363 | CAPN3; calpain 3 (p94) [EC:3.4.22.17] |
| CAPN5 | GeneProduct | ncbigene:451438 | CAPN5; calpain |
| CAPN7 | GeneProduct | ncbigene:460202 | CAPN7; calpain 7 [EC:3.4.22.17 |
| CAPN9 | GeneProduct | ncbigene:457812 | CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17 |
| CAPN11 | GeneProduct | ncbigene:462727 | CAPN11; calpain 11 [EC:3.4.22.17] |
| CAPN6 | GeneProduct | ncbigene:465810 | CAPN6; calpain 6 [EC:3.4.22.17] |
| PAK2 | GeneProduct | ncbigene:460965 | PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-] |
| PAK3 | GeneProduct | ncbigene:450118 | PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-] |
| MAP2K3 | GeneProduct | ncbigene:454515 | MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-] |
| MAP2K5 | GeneProduct | ncbigene:453532 | MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-] |
| MAP2K6 | GeneProduct | ncbigene:468310 | MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.- |
| AKT3 | GeneProduct | ncbigene:735718 | AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-] |
| DOCK1 | GeneProduct | ncbigene:739420 | DOCK1; dedicator of cyto-kinesis |
| CRK | GeneProduct | ncbigene:747142 | CRK; v-crk sarcoma virus CT10 oncogene homolog (avian |
| RAPGEF1 | GeneProduct | ncbigene:464812 | GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene |
| RAP1A | GeneProduct | ncbigene:469408 | RAP1A; RAP1A member of RAS oncogene family |
| RAP1B | GeneProduct | ncbigene:452065 | RAP1B; RAP1B member of RAS oncogene family |
| MAPK1 | GeneProduct | ncbigene:458680 | MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-] |
| MAPK6 | GeneProduct | ncbigene:453439 | MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-] |
| MAP2K1 | GeneProduct | ncbigene:450188 | MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-] |
| MAP2K2 | GeneProduct | ncbigene:456390 | MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-] |
| CAPN1 | GeneProduct | ncbigene:451317 | CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17] |
| ITGA2 | GeneProduct | ncbigene:471550 | |
| ITGA3 | GeneProduct | ncbigene:455111 | |
| ITGA4 | GeneProduct | ncbigene:470596 | |
| ITGA5 | GeneProduct | ncbigene:451958 | |
| ITGA6 | GeneProduct | ncbigene:459742 | |
| ITGA8 | GeneProduct | ncbigene:450323 | |
| ITGA9 | GeneProduct | ncbigene:470789 | |
| ITGA10 | GeneProduct | ncbigene:457982 | |
| ITGA11 | GeneProduct | ncbigene:453537 | |
| ITGA2B | GeneProduct | ncbigene:454730 | |
| ITGAD | GeneProduct | ncbigene:468103 | |
| ITGAL | GeneProduct | ncbigene:454045 | |
| ITGAM | GeneProduct | ncbigene:454069 | |
| ITGAV | GeneProduct | ncbigene:459807 | |
| ITGAX | GeneProduct | ncbigene:454070 | |
| ITGB1 | GeneProduct | ncbigene:450396 | |
| ITGB2 | GeneProduct | ncbigene:458607 | |
| ITGB3 | GeneProduct | ncbigene:468295 | |
| ITGB4 | GeneProduct | ncbigene:454887 | |
| ITGB5 | GeneProduct | ncbigene:460646 | |
| ITGB6 | GeneProduct | ncbigene:459683 | |
| ITGB7 | GeneProduct | ncbigene:451934 | |
| ITGB8 | GeneProduct | ncbigene:463282 | |
| SRC | GeneProduct | ncbigene:458229 | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
| VCL | GeneProduct | ncbigene:450531 | VCL; vinculin |
| TNS1 | GeneProduct | ncbigene:459934 | TNS; tensi |
| MAPK10 | GeneProduct | ncbigene:461358 | |
| PXN | GeneProduct | ncbigene:452303 | PXN; paxillin |
| ILK | GeneProduct | ncbigene:748941 | ILK; integrin-linked kinase [EC:2.7.1.-] |
| PAK1 | GeneProduct | ncbigene:451439 | PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-] |
| VASP | GeneProduct | ncbigene:468919 | VASP; vasodilator-stimulated phosphoprotein |
| ITGA7 | GeneProduct | ncbigene:451967 | |
| ITGA1 | GeneProduct | ncbigene:461880 |
References
- Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia