Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle.
Source: [[wikipedia:Integrins|Wikipedia]]
This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP185&oldid=21067 WP185(r21067)] with a 70% conversion rate.
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CDC42; cell division cycle 42 (GTP binding protein 25kD)
SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3; neuronal Sh
ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
VAV2; vav 2 oncogene
VAV3; vav 3 oncogene
ROCK2; Rho-associated coiled-coil containing protein kinase
ROCK1; Rho-associated coiled-coil containing protein kinase
SH3D5; SH3-domain protein 5 (ponsin
SOS1; son of sevenless homolog 1 (Drosophila)
GIT2; G protein-coupled receptor kinase-interactor 2
PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ZYX; zyxin
CAV1; caveolin 1 caveolae protein 22kD
CAV2; caveolin 2
CAV3; caveolin 3
FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GRB2; growth factor receptor-bound protein 2
SEPP1; selenoprotein P plasma
PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
CSK; c-src tyrosine kinase [EC:2.7.1.112]
BCAR1; breast cancer anti-estrogen resistance 1
SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5; calpain
CAPN7; calpain 7 [EC:3.4.22.17
CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPN10; calpain 10 [EC:3.4.22.17
CAPN11; calpain 11 [EC:3.4.22.17]
CAPN6; calpain 6 [EC:3.4.22.17]
PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6; p21(CDKN1A)-activated kinase
TLN1; talin 1
MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
DOCK1; dedicator of cyto-kinesis
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RAP1A; RAP1A member of RAS oncogene family
RAP1B; RAP1B member of RAS oncogene family
MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
VCL; vinculin
TNS; tensi
PXN; paxillin
ILK; integrin-linked kinase [EC:2.7.1.-]
PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
VASP; vasodilator-stimulated phosphoprotein
integrin mediated signaling pathway
PW:0000286
Pathway Ontology
16125000
PubMed
Assembly and signaling of adhesion complexes.
Curr Top Dev Biol
2005
Sepulveda JL
Gkretsi V
Wu C