Peroxiredoxin 2 induced ovarian failure (WP4835)
Mus musculus
This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.
Authors
Bas Lahaije , Laurent Winckers , Friederike Ehrhart , and Egon WillighagenCited In
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Organism
Mus musculusCommunities
Rare DiseasesAnnotations
Pathway Ontology: signaling pathway c-Jun N-terminal kinases MAPK signaling pathway
Disease Ontology: ovarian dysfunction
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Reactive oxygen species | Metabolite | chebi:26523 | |
| Estradiol-17beta | Metabolite | chebi:16469 | |
| Progesterone | Metabolite | chebi:17026 | |
| PARP | Metabolite | chebi:62913 | |
| Bax | GeneProduct | ensembl:ENSMUSG00000003873 | |
| Cytochrome c | Protein | uniprot:P62897 | Somatic |
| CYP11A1 | Protein | uniprot:Q9QZ82 | Mitochondrial |
| 3Beta-HSD | Protein | uniprot:E9PXG7 | |
| JNK | Protein | ensembl:ENSMUSP00000023291 | |
| Caspase-3 | Protein | uniprot:A0A1B0GRX1 | |
| StAR | Protein | uniprot:P51557 | MitichondrialType your comment here |
| Peroxiredoxin-2 | Protein | uniprot:Q61171 |
References
- Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS. Free Radic Biol Med. 2018 Aug 1;123:96–106. PubMed Europe PMC Scholia