Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/). * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC Assay Portal]

Authors

Kristina Hanspers , Jonathan Mlius , Andika Tan , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Disease Ontology: hepatocellular carcinoma

Pathway Ontology: disease pathway

Participants

References

1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, et al. How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Hepat Mon. 2016 Feb 20;16(2):e36005. PubMed Europe PMC Scholia