mir-124 predicted interactions with cell cycle and differentiation (WP3595)
Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.
AuthorsKristina Hanspers , Ryan Miller , and Martina Summer-Kutmon
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- Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling (2021).
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Pathway Ontologyregulatory pathway
- A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia