Gonadotropin-releasing hormones (GnRH) are the key factors stimulating gonadotropin release from the pituitary. GnRHs are decapeptides that act via G-protein coupled receptors (gonadotropin-releasing hormone receptors, GnRH-R). To date, several molecular forms of GnRH and GnRH-R have been identified in vertebrates. In most species, two forms of GnRH are present. one that is hypophysiotropic, stimulating gonadotropin release from the pituitary, and one that plays a neuromodulatory role in the central nervous system. The pituitary gonadotropins are heterodimeric glycoprotein-hormones consisting of a non-covalently linked common glycoprotein-hormone α-subunit and a specific β-subunit (FSHβ or LHβ) conferring their biological activity(2)

Authors

Zahra Roudbari , Martina Summer-Kutmon , Egon Willighagen , Jonathan Mlius , and Alex Pico

Cited In

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Organism

Bos taurus

Communities

Annotations

Cell Type Ontology: gonadotropin releasing neuron

Pathway Ontology: signaling pathway

Participants

References

1. Kim HH. Regulation of gonadotropin-releasing hormone gene expression. Semin Reprod Med. 2007 Sep;25(5):313–25. PubMed Europe PMC Scholia
2. Widmann P, Reverter A, Fortes MRS, Weikard R, Suhre K, Hammon H, et al. A systems biology approach using metabolomic data reveals genes and pathways interacting to modulate divergent growth in cattle. BMC Genomics. 2013 Nov 18;14:798. PubMed Europe PMC Scholia