The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).

Authors

Zahra Roudbari , Martina Summer-Kutmon , Chris Evelo , Egon Willighagen , Kristina Hanspers , Jonathan Mélius , and Eric Weitz

Cited In

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Organism

Bos taurus

Communities

Annotations

Pathway Ontology: signaling pathway

Participants

References

1. Insulin-like growth factors and their binding proteins: biological actions. Jones JI, Clemmons DR. Endocr Rev. 1995 Feb;16(1):3–34. PubMed Europe PMC Scholia
2. The IGF1 pathway genes and their association with age of puberty in cattle. Fortes MRS, Li Y, Collis E, Zhang Y, Hawken RJ. Anim Genet. 2013 Feb;44(1):91–5. PubMed Europe PMC Scholia