Acetylcholine synthesis (WP1034)
Bos taurus
Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.
Authors
Thomas Kelder , Christine Chichester , Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , Asios Olia , and Eric WeitzCited In
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Organism
Bos taurusCommunities
Annotations
Pathway Ontology: acetylcholine metabolic pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Cytidine diphosphate choline | Metabolite | hmdb:HMDB0001413 | |
| Phosphatidylethanolamine | Metabolite | hmdb:HMDB0060501 | |
| Phosphorylcholine | Metabolite | hmdb:HMDB0001565 | |
| Acetylcholine | Metabolite | cas:51-84-3 | |
| Choline | Metabolite | cas:62-49-7 | |
| Glycerophosphocholine | Metabolite | cas:28319-77-9 | |
| Phosphatidylcholine | Metabolite | hmdb:HMDB0000564 | |
| Pyruvate from Glycolysis | Metabolite | hmdb:HMDB0000243 | |
| Acetyl CoA | Metabolite | cas:72-89-9 | |
| Acetate | Metabolite | cas:64-19-7 | |
| Choline | Metabolite | cas:62-49-7 | |
| PCYT1A | GeneProduct | ensembl:ENSBTAG00000016979 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5130 |
| PDHA2 | GeneProduct | ensembl:ENSBTAG00000026250 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161 |
| ACHE | GeneProduct | ensembl:ENSBTAG00000001139 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43 |
| PDHA1 | GeneProduct | ensembl:ENSBTAG00000019852 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160 |
| PEMT | GeneProduct | ensembl:ENSBTAG00000016432 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10400 |
| CHKA | GeneProduct | ensembl:ENSBTAG00000010304 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1119 |
| CHAT | GeneProduct | ensembl:ENSBTAG00000016814 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1103 |
References
- Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia
- Acetylcholine synthesis and possible functions during sea urchin development. Angelini C, Baccetti B, Piomboni P, Trombino S, Aluigi MG, Stringara S, et al. Eur J Histochem. 2004;48(3):235–43. PubMed Europe PMC Scholia
- Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A. Neurochem Res. 2013 Aug;38(8):1523–42. PubMed Europe PMC Scholia