ArcPathVisio
Brace
Octagon
Ellipse
EndoplasmicReticulum
HexagonPathVisio
GolgiApparatus
MimDegradation
Mitochondria
Octagon
PentagonPathVisio
Rectangle
RoundedRectangle
SarcoplasmicReticulum
TrianglePathVisio
none
Mitochondrion
DNA repair
Legend
9-1-1 complex
HUS1
RAD1
RAD9A
DNA adduct
G2/M transition
Chromatin alteration
Activation
Blocked replication
G2/M checkpoint
Chromatin
remodeling
G2/M checkpoint
ROS
Cell-cycle progression
Endogenous:
Collapsed replication forks
Single stranded DNA replication breaks
Free radicals (ROS)
Inhibition
Change in cell condition
DNA damage source
Double-strand breaks
Specialized:
Somatic hypermutaion
V(D)J recombination
Class switching
Replication stress
Blocked transcription
Bulky DNA lesion
ROS
Exogenous:
Cigarette smoke
Caffeine
Radiation (UV)
Clastogenes
Genotoxic drugs
Hypoxia
Cell survival
DNA repair and
damage prevention
AKT1
DNA damage
ATM dependent
RB1
E2F1
CDC25C
CASP8
CCNB1
CCNB3
CCNB2
MRE11
RAD50
NBN
CHEK1
ATR
Caffeine
G1/S transition
CDKN1A
RAD52
c-Myc
CASP3
MDM2
CDK6
CCND3
CCND1
CDK5
CDK4
CCND2
DDB2
SESN1
RRM2B
GADD45G
GADD45B
GADD45A
PML
BID
TP53AIP1
PMAIP1
BBC3
BAX
H2AFX
FANCD2
GADD45A
GADD45B
GADD45G
FAS
PIDD
TNFRSF10B
Cell cycle
CYCS
CDC2
RB1
7-hydroxystaurosporine
RAD51
CDKN1B
CDK2
CCNE1
CCNE2
SFN
ATRIP
RPA2
TP53
TLK1
TLK2
RAD17
RFC
BRCA1
CHEK2
SMC1A
Estradiol
CREB
ABL1
PRKDC
APAF1
CASP9
E2F1
CDC25A
Senescence
Apoptosis
Alkylating agents
ATM
Name: DNA damage response
Last Modified: 20240221125323
Organism: Homo sapiens