The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP382_r95114 WP382 (r95114)] with a 98.0% conversion rate.a74f20b95d24d71ecba36c2bb12Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7189Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4208Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6722Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6197Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5606Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158711Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5906Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1398Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3552Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5155Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10000Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51295Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9175Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:115727Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6885Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5601Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2885Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8569Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1843Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3925Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2002Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1956Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5532Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5533Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11184Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4772Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:409Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4137Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10125No homologues found for original id L:5908Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:929Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8517Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:627Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1616Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5602Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7124Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4342Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000101109Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1432Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3551Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:408Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000188906Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:836Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2316Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5566Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9261Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000067182Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000006062Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3315Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51776Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2768Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7040Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4214Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10746Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4149Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11221Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5924Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9448Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5159Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10454Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4216Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1647Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5607Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:994Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3554Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5880Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5580Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5536Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5604Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5879Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5778Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7850Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23118Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7046Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5594Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5801Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84867Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000159337Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:673Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4914Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1386Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6416Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2353Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5582Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6655Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7042Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2002Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5598Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1846Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = H:CACNG3Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3312Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6300Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000121653Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5494Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3553Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158711Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7186Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5603Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:57551Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5608Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000184545Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:208Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8550Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5922Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1849No homologues found for original id L:5535Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2260Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7043Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5530Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1950Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1649Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9064Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1326Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000134259Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1399Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9344Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5595Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5599Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3164Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000154229Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:468Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000225950Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000197461Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:468Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000148053Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:356Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000113721Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5495Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000066468Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:998Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000068078Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8649Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000160867No homologues found for original id L:3725Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000115904Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3727Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000126458Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000174775Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9252Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7786Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000133818Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4790Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000172380Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105499Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196712Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000068831Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:207Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000152689Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000171777Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5921Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000058335Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000173110Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000185652Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000109756Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000142875Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3303Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000165059Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6788Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000108861Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8491Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000213341Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7048Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000077150Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000168067Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000173039Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5609Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000104856No homologues found for original id L:5534Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000130829Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51701Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158050Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000111266Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:355Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000099875Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000116711Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000072736Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4217Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4296Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000135090Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1848Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5605No homologues found for original id En:ENSG00000230510Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000185386Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000162302Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000114738Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000169750Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000008735Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138834Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000136068Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000128591Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000204388Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000204390Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000126803Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:22808Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4893Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3845Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5894Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000168907Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000243708Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000188089Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000166862Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075429Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075461Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000157445Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000142408Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105605Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000130433Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000141837Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000148408Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000151067Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000157388Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000198216Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102001Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000081248Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000153956Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000067191Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000165995Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000167535Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000182389Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000108878Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000100346Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196557Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000006283Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000007402Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000151062Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2249Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000113578Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138685Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000186895Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075388Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138675Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000111241Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000140285Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000107831Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102678Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000070193Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000161958Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000114279Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000129682Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102466Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000078579Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105550Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000070388Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000118972Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000156427Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158815Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196468Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000162344Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5062Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5058Stathmin is a ubiquitous phsosphorylated proteinhttps://en.wikipedia.org/wiki/Stathmin#Functionparentid=P19419; position=ser389; ptm=p; direction=uparentid=P19419; position=ser383; ptm=p; direction=uparentid=P19419; position=ser324; ptm=p; direction=uPresumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitoryparentid=P61224; position=ser179; ptm=p; direction=uparentid=O14920; position=ser181; ptm=p; direction=uparentid=O14920; position=ser177; ptm=p; direction=uhttps://en.wikipedia.org/wiki/I%CE%BAB_kinase#RegulationG2019Sparentid=Q02750; position=ser222; ptm=p; direction=uparentid=Q02750; position=ser218; ptm=p; direction=uparentid=P28482; position=thr185; ptm=p; direction=uparentid=P28482; position=tyr187; ptm=p; direction=uparentid=P27361; position=thr202; ptm=p; direction=uparentid=P27361; position=tyr204; ptm=p; direction=uparentid=P05412; position=ser73; ptm=p; direction=uparentid=P05412; position=ser63; ptm=p; direction=uparentid=O15111; position=thr23; ptm=p; direction=uhttps://en.wikipedia.org/wiki/I%CE%BAB_kinase#RegulationPresumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitoryparentid=P36507; position=ser226; ptm=p; direction=uparentid=P36507; position=ser222; ptm=p; direction=uea5e69MAPK signaling pathwayPW:0000007Pathway Ontologymitogen activated protein kinase signaling pathwayPW:0000007Pathway Ontology11749383PubMedMAP kinases.Chem Rev2001Chen ZGibson TBRobinson FSilvestro LPearson GXu BWright AVanderbilt CCobb MH12191611PubMedDocking interactions in the mitogen-activated protein kinase cascades.Pharmacol Ther2002Tanoue TNishida E12947395PubMedMAPK pathways in radiation responses.Oncogene2003Dent PYacoub AFisher PBHagan MPGrant S12676795PubMedTrk receptors: roles in neuronal signal transduction.Annu Rev Biochem2003Huang EJReichardt LF11369511PubMedSignalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.Cell Signal2001Harper SJLoGrasso P12390245PubMedNeuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.Genes Cells2002Takeda KIchijo H14597384PubMedTranscriptional regulation by the MAP kinase signaling cascades.Gene2003Yang SHSharrocks ADWhitmarsh AJ12566928PubMedThe role of mitogen-activated protein kinase pathways in Alzheimer's disease.Neurosignals2002Zhu XLee HGRaina AKPerry GSmith MA12849693PubMedSilica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.Toxicol Lett2003Cho HLee JKwak NJLee KHRha SKim YHCho YYYang KHKim KLim Y17726008PubMedMEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.J Biol Chem2007Abell ANGranger DAJohnson GL22539006PubMed(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.Cell Death Differ2012Chen CYWeng YHChien KYLin KJYeh THCheng YPLu CSWang HL