ArcPathVisio
Brace
Octagon
Ellipse
EndoplasmicReticulum
HexagonPathVisio
GolgiApparatus
MimDegradation
Mitochondria
Octagon
PentagonPathVisio
Rectangle
RoundedRectangle
SarcoplasmicReticulum
TrianglePathVisio
none
Overproduction of fibrofatty
tissue in myocardium
Chaotic
apoptosis and/or necrosis
DNA fragmentation
within nucleus
Inflammation
Symptomatic arrhythmias
Formation of
caveosomes
for CVB3 uptake
CAR/DAF
complex
Apoptosis type I & II
Dystrophin deficiency leads to
loss of the sarcoglycan complex
pre-cursor to DCM
Increased expr.
Adjacent cardiomyocytes
HIV
Extracellular matrix
AD2
Degeneration
Viral antigens
Sarcomer
CVB1
Primary
profibrotic
cytokine
Phosphorylated dimers
move to nucleus
stimulate gene expression
Mature secreted forms
Degradation
CVB3
HIV-triggered immune-mediated myocarditis
beta catenin pathway
B cell
Viral genomic RNA
Max. release of
progeny virion
Myocyte necrosis
Fibrosis
Myocyte atrophy
Type I induced apoptosis
DNA
fragmentation
CD8*T cell
Viral replication,
inactivation of p21ras
CVB 1 3 5 can all bind to both CAR and DAF
Viral progeny
release
Nucleus
Coxsackie B virus
Ubiquitin-proteasome system
Matrix degradation
Sarcoplasm
HIV-1
Autoreactive
antibodies
Host protein synthesis shutoff
induction of CPE
Apoptotic cardiomyocyte
ER
Sarcolemma
Enterovirus-induced
cardiomyopathy
Type II induced apoptosis
Virus-specific
antibodies
Myocyte dysfunction
Dystrophin
Decreased force transmission
Increased cell permeability
Sarcoglycan complex
Adenovirus
Cell cycle arrest
Cellular activation
Suppresses
cytopathic
effects
Loss of mechanical
stability of the cell
Myosin
Actin
reorganization
Viral replication
Mitochondrion
CD4*T cell
Antigen presenting cell
Calcium pump
Myocyte
AD2 and 5 solely bind the CAR
HIV-2
T cell receptor
signaling pathway
Immune-mediated
myocyte damage
t-Bid
SOCS1
Nitric oxide synthase
IFNG
TGFB1
JAK1
STAT1
ECM-receptor interaction
IL10
IL6
ganglioside GM1
Endothelin-1
STAT3
EIF4G2
CASP8
ACTB
prostaglandin E2
BAX
ATF-2
SGCB
ILK
CD4
3C^PRO
2A^PRO
FYN
MMP9
DAF
RAC2
CHRAC1
RAC3
ABL1
ABL2
BCL2L1
BCL2
RAF-1
CASP2
CASP6
CASP7
MK2
pro-IL-1beta
Pro-IL-18
Tyrosine kinase
NOD2
CCR5
TLR3
CYCS
MEK 1/2
PTCRA
p53
CCND1
TNF-a
BH3 Bid
peptidoglycan muramyl
dipeptide
Catenin beta-1
IgG
Herbimycin A
glycophosphatidylinositol
IL1
MKK 3/6
Ca2+
AIF1
JNK1
TICAM1
SOS1
MAPK1
RASA1
SRC
SGCA
TNFRSM5
DFFB-45
DFFA/ICAD
GSK3B
AKT1
MHCII
MHC-1
CD55
CAR
CXADR
Viral entry
CVB3
T cell receptor alpha chain V region
T-cell receptor beta chain V region
SGCD
HLA-DMA
ENDOG
TLR4
IL1
PYCARD
NLRP3
hsp27
c-Jun
Perforin-1
PIK3
Cd28
ITGAL
LAMA2
CREB1
CXCR4
ITGB2
NFKB2
CASP3
Matrix metalloproteinases
IL12A
IL12B
KRT8
MYH6
IL2
DMD
135 S A-particle
DAP5
DAG1-B
TLR5
Striated muscle
contraction
CASP9
MKK 4/7
CCR3
Dystrophin
DAG1-a
Macrophage
EIF4G1
SGCG
CD40LG
BNIP2
PAR
Myocarditis
reactive oxygen species generators
NF-kB
MAPK3
MAPK1
CD80
CAV1
IgG
cd86
glycophosphatidylinositol
BH3 Bid
Ca2+
Nucleus
PTCRA
Decreased expr.
Increased expr.
? Promotes tissue fibrosis ?
CAAP1
PARP1
PABPC1
Proteasome
Cardiac antigens
antigen
antigen
Name: Acute viral myocarditis
Last Modified: 20240222221503
Organism: Homo sapiens