The major function of the distal convoluted tubule 1 cell (DCT1 cell) in the kidney is to maintain proper iron, solute and water homeostasis. The cells are polarized and located in the nephron duct where they have unique transport functions which are maintained by specialized K(+), Na(+), and Cl(-) channels in the proximal or distal part of the cell.f4btransporting cellCL:0000627Cell Ontologyregulatory pathwayPW:0000004Pathway OntologyBartter diseaseDOID:445Human Disease Ontologytransport pathwayPW:0000103Pathway Ontologykidney epithelial cellCL:0002518Cell Ontologykidney loop of henle thick ascending limb epithelial cellCL:1001106Cell Ontologykidney distal convoluted tubule epithelial cellCL:1000849Cell Ontology26654186PubMedRoles and Regulation of Renal K Channels.Annu Rev Physiol2016Welling PA