(Nanoparticle) induced lung fibrosis pathway.
Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are encouraged to add this information when available.b2aHuman pathway - mouse not yet availableHuman pathway - mouse not yet availablef19Human gene product - no annotation for mouse yetHuman gene product - no annotation for mouse yete55Human pathway - mouse pathway not yet availablee55Link to the pathway Endochondrial ossification describing chondrocyte differentiation. Chondrocytes produce and maintain cartilage consisting mainly of collagen and proteoglycans.f5dLink to Elastic fibre formation, which describes the dynamic connective tissues such as large arteries and lung parenchyma. The stress fibre assembly related gene ELN is involved in this pathway.Human pathway, mouse is not yet availablea8bHuman pathway - mouse not available yetf19pulmonary fibrosisDOID:3770Human Disease Ontologyrespiratory system disease pathwayPW:0001308Pathway Ontology29149350PubMedA data fusion pipeline for generating and enriching Adverse Outcome Pathway descriptions.Toxicol Sci2017Nymark PRieswijk LEhrhart FJeliazkova NTsiliki GSarimveis HEvelo CTHongisto VKohonen PWillighagen EGrafström RC26979667PubMedNano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubeshttp://www.ncbi.nlm.nih.gov/pubmed/269796672016Labib SWilliams AYauk CLNikota JKWallin HVogel UHalappanavar S22824096PubMedMolecular and cellular mechanisms of pulmonary fibrosis.http://www.ncbi.nlm.nih.gov/pubmed/228240962012Todd NWLuzina IGAtamas SP26926090PubMedMechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).2016Vietti GLison Dvan den Brule S25326323PubMedThe Comparative Toxicogenomics Database's 10th year anniversary: update 2015http://www.ncbi.nlm.nih.gov/pubmed/253263232015Davis APGrondin CJLennon-Hopkins KSaraceni-Richards CSciaky D2, King BLWiegers TC2, Mattingly CJ25254104PubMedGeneMANIA: Fast gene network construction and function prediction for Cytoscape.http://www.ncbi.nlm.nih.gov/pubmed/252541042014Montojo JZuberi KRodriguez HBader GDMorris Q8634065PubMedThe chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules.Bioessays. 1995 Dec;17(12):1039-48.1995Muir H.18755000PubMedMechanisms of actin stress fibre assemblyJ Microsc. 2008 Sep;231(3):446-54. doi: 10.1111/j.1365-2818.2008.02057.x.2008Naumanen P, Lappalainen P, Hotulainen P