A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.
Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal]a0fa2aparentid=Q05397; parentsymbol=FAK; site=PIGNQHIyQPVGKPD; position=tyr861; sitegrpid=447965; ptm=p; direction=uparentid=Q04759; parentsymbol=PRKCQ; site=LGDAktNtFCGtPDy; position=thr538; sitegrpid=447907; ptm=p; direction=uparentid=P19174; parentsymbol=PLCG1; site=EGRNPGFyVEANPMP; position=tyr783; sitegrpid=447667; ptm=p; direction=uparentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyr; position=tyr204; sitegrpid=447543; ptm=p; direction=uparentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u25514926PubMedPhosphoSitePlus, 2014: mutations, PTMs and recalibrations.Nucleic Acids Res2015Hornbeck PVZhang BMurray BKornhauser JMLatham VSkrzypek Edisease pathwayPW:0000013Pathway Ontologycancer pathwayPW:0000605Pathway Ontologyovarian cancerDOID:2394Diseasedisease of cellular proliferationDOID:14566Disease25277212PubMedCalcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.Nat Commun2014Leung CSYeung TLYip KPPradeep SBalasubramanian LLiu JWong KKMangala LSArmaiz-Pena GNLopez-Berestein GSood AKBirrer MJMok SC