ArcPathVisio
Brace
Octagon
Ellipse
EndoplasmicReticulum
HexagonPathVisio
GolgiApparatus
MimDegradation
Mitochondria
Octagon
PentagonPathVisio
Rectangle
RoundedRectangle
SarcoplasmicReticulum
TrianglePathVisio
none
P
MAPK9
P
SMAD3
P
MAPK3
P
SMAD3
P
STAT5B
P
IKBKB
AGER
P
MMP2
MMP14
MMP13
MMP9
MMP7
CML
CEL
AGE-modified albumin
Pentosidine
Glyc-FBS
CML-Collagen
Neurite
Calcification of smooth muscle cells
AGE/RAGE Signaling Pathway
P
AGER
GTP
CDC42
Gg
GTP
RAC1
GTP
RHOA
CASP3
IRS1
P
PRKCA
MYD88
IRAK4
P
MSN
TIRAP
P
ROCK1
GTP
INHBB
P
SRC
P
MAPK1
deP
FOXO1
SP1
P
NFKB1
P
RELA
P
deP
AKT1
P
MAPK14
P
MAPK8
FOXO4
P
JAK2
P
STAT1
P
STAT3
P
CHUK
CASP8
P
Ub
BIKBA
P
NFKB1
P
RELA
P
SMAD2
P
SMAD2
Tubular epithelium myofibroblast transition
DIAPH1
PLC
P
PLA2G4A
Na+ K+ ATPase
Neutrophil
Rearrangement of the actin cytoskeleton
Autophagy in vascular smooth muscle cells
Dissolution of gap junctions in human hepatoma cells
Cell proliferation
P
ATF2
P
JUN
Fibroblasts
CASP9
Retinal pericytes
Osteoblasts
INS-1 cells
NO
Neuroblastoma cells
Increase in monolayer permeability
Renal cellular hypertrophy
Mitogeneis in NRK-49F cells
P
MAP2K1
P
RAF1
ALPL
Monocyte adhesion to retinal endothelial cells
P
NCF1
P
STAT5A
SP1
NOX
Apoptosis in
FOXO1
FOXO4
Osteogenic
differentiation
of VSMCs
Renal proximal tubular cells
INOS
NOS3
Inhibition of
Endothelial cell
Degradation
Dissociation
H2O2
Mitochondrial
PRKCB
PRKCZ
Protein
Dissociation of PPI
Receptor
Protein
Transport
Leads to
Induced catalysis
Protein-protein interaction (PPI)
LEGEND
Phosphorylation
Nucleus
Cytoplasm
CY
NU
Enzyme
Enzyme complex or
specific component unknown
CY
NU
CY
NU
CY
NU
CY
NU
CY
NU
CY
NU
Ligand
Small molecules
Enzyme
Proteins activated (identified by assays)
MT
Mitochondria
CY
MT
Apoptosis in
Podocytes
Fibroblasts
CYCS
CYCS
SOD1
burst
TGF-beta
independent
Dephosphorylation
Inhibition of proliferation and migration of
bone marrow mesenchymal stem cells
T-cells
Endothelial cell permeability
PIP2
DAG
Ca2+
Arachidonic acid
ROS
outgrowth
permeability
transition
dysfunctions
Phosphorylated state
Ub
Ubiquitinated state
Gg
Geranylgeranylated state
deP
Dephosphrylated state
Regulation of
cytoskeleton
Formation of F-actin stress fibers
P
SHC1
P
EGFR
DDOST
Internalization
AGE removal
and
AGEs
MSR1
AGEs
INS
IR-A
HIF1A
HIF1A
CY
NU
Inhibition of
tubulogenesis of
proximal tubule cells
P
deP
EZR
Placenta and
gestational membranes
Prostaglandin F2alpha
Prostaglandin E2
Released from
Chondrocytes
LGALS3
AGEs
increased
P
PRKCD
Microglial cells
Name: AGE/RAGE pathway
Last Modified: 20161006112455
Organism: Bos taurus