'''Aflatoxins''' are naturally occurring [[wikipedia:mycotoxin|mycotoxin]]s that are produced by many species of ''[[wikipedia:Aspergillus|Aspergillus]]'', a [[wikipedia:fungus|fungus]], most notably ''[[wikipedia:Aspergillus flavus|Aspergillus flavus]]'' and ''[[wikipedia:Aspergillus parasiticus|Aspergillus parasiticus]]''. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M<sub>1</sub>, an [[wikipedia:epoxide|epoxide]]. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus.
Source: [[wikipedia:Aflatoxin|Wikipedia]]This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP699&amp;amp;oldid=30253 WP699(r30253)] with a 58% conversion rate.c71b3ab7aae4fe0ee4a84cb5a49e9fce3e9fce3aflatoxin metabolic pathwayPW:0001366Pathway Ontology16584116PubMedCytochrome P450s and other enzymes in drug metabolism and toxicity.AAPS J2006Guengerich FP11440964PubMedRole of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.Cancer Epidemiol Biomarkers Prev2001Tiemersma EWOmer REBunschoten Avan't Veer PKok FJIdris MOKadaru AMFedail SSKampman E12724730PubMedTranslational strategies for cancer prevention in liver.Nat Rev Cancer2003Kensler TWQian GSChen JGGroopman JD12067245PubMedReaction of aflatoxin B(1) oxidation products with lysine.Chem Res Toxicol2002Guengerich FPArneson KOWilliams KMDeng ZHarris TM11409944PubMedReduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.Chem Res Toxicol2001Guengerich FPCai HMcMahon MHayes JDSutter TRGroopman JDDeng ZHarris TM10506113PubMedGlutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.Carcinogenesis1999Stewart RKSmith GBDonnelly PJReid KRPetsikas DConlan AAMassey TE18949601PubMedThe aldo-keto reductase superfamily and its role in drug metabolism and detoxification.Drug Metab Rev2008Barski OATipparaju SMBhatnagar A16970545PubMedAldo-keto reductases and bioactivation/detoxication.Annu Rev Pharmacol Toxicol2007Jin YPenning TM1504254PubMedThe endo-8,9-epoxide of aflatoxin B1: a new metabolite.Chem Res Toxicol1992Raney KDColes BGuengerich FPHarris TM16815959PubMedCYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.Drug Metab Dispos2006Zhu LRThomas PELu GReuhl KRYang GYWang LDWang SLYang CSHe XYHong JY16385575PubMedEfficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.Int J Cancer2006He XYTang LWang SLCai QSWang JSHong JY