The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]''
This pathway is based on ScienceSlides.This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP581&oldid=22574 WP581(r22574)] with a 100% conversion rate.d08d1eNot sure if complex consists of both A and B isoforms [thomas-081110]erythropoietin signaling pathwayPW:0000987Pathway Ontology10334664PubMedThe molecular biology of erythropoietin.Nephrol Dial Transplant1999Lacombe CMayeux P9371269PubMedThe molecular physiology of erythropoietin and the erythropoietin receptor.Curr Opin Hematol1994Zhu YD'Andrea AD