Transcriptional activation by NRF2 (WP988)

Bos taurus

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Based on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in oxidative stress response.

Authors

Egon Willighagen and Martina Summer-Kutmon

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

nuclear factor, erythroid 2 like 2 signaling pathway oxidative stress response pathway

Participants

Label Type Compact URI Comment
Sulforaphane Metabolite hmdb:HMDB0005792
6-HITC Metabolite chemspider:7991398 Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl ester Metabolite chebi:8062
Curcumin Metabolite hmdb:HMDB0002269
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
AIMP2 GeneProduct ensembl:ENSBTAG00000007367 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7965
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
KEAP1 GeneProduct ensembl:ENSBTAG00000003543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9817
GCLC GeneProduct ensembl:ENSBTAG00000015571 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
HMOX1 GeneProduct ensembl:ENSBTAG00000015582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3162
MAF GeneProduct ensembl:ENSBTAG00000044192 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4094
EPHB2 GeneProduct ensembl:ENSBTAG00000045902 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2939
NQO1 GeneProduct ensembl:ENSBTAG00000020632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
KEAP1 GeneProduct ensembl:ENSBTAG00000003543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9817
SLC7A11 GeneProduct ensembl:ENSBTAG00000034075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012

References

  1. Cancer chemoprevention with dietary phytochemicals. Surh YJ. Nat Rev Cancer. 2003 Oct;3(10):768–80. PubMed Europe PMC Scholia