Cell cycle (WP964)

Pan troglodytes

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Martijn Van Iersel , Martina Summer-Kutmon , and Lauren J. Dupuis


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Pan troglodytes



Pathway Ontology

cell cycle pathway


Label Type Compact URI Comment
PTTG1 GeneProduct ncbigene:462238 PTTG1; pituitary tumor-transforming
CDKN2A GeneProduct ncbigene:465021
YWHAG GeneProduct ncbigene:463489 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
CDK6 GeneProduct ncbigene:746968 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CCNA2 GeneProduct ncbigene:461467 CCNA2; cyclin A2
CDC20 GeneProduct ncbigene:456819 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
MPEG1 GeneProduct ncbigene:451211
CCNE2 GeneProduct ncbigene:464292 CCNE2; cyclin E
CDC25B GeneProduct ncbigene:458064 CDC25B; cell division cycle 25B [EC:]
ORC4L GeneProduct ncbigene:459647 ORC4L; origin recognition complex subunit 4-like (yeast)
RB1 GeneProduct ncbigene:452715 RB1; retinoblastoma 1 (including osteosarcoma)
TBC1D8 GeneProduct ncbigene:459451
CCND2 GeneProduct ncbigene:747123 CCND2; cyclin D2
PRKDC GeneProduct ncbigene:464165 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:]
EP300 GeneProduct ncbigene:458862 EP300; E1A binding protein p300
ORC3L GeneProduct ncbigene:462876 ORC3L; origin recognition complex subunit 3-like (yeast)
BUB3 GeneProduct ncbigene:450800 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CHEK2 GeneProduct ncbigene:458733 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
LOC466968 GeneProduct ncbigene:466968 HDAC7A; histone deacetylase 7
RB1 GeneProduct ncbigene:452715 RB1; retinoblastoma 1 (including osteosarcoma)
MDM2 GeneProduct ncbigene:742141 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MCM7 GeneProduct ncbigene:472460 MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
CDC14A GeneProduct ncbigene:457058 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
LOC465712 GeneProduct ncbigene:465712 HDAC8; histone deacetylase
CCNH GeneProduct ncbigene:739351 CCNH; cyclin H
LOC464259 GeneProduct ncbigene:464259 HDAC1; histone deacetylase 1
CDKN1B GeneProduct ncbigene:466947 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
RBL1 GeneProduct ncbigene:735916
MAD2L1 GeneProduct ncbigene:461661 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CCNB2 GeneProduct ncbigene:453478 CCNB2; cyclin B2
CDK2 GeneProduct ncbigene:467032 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
LOC454721 GeneProduct ncbigene:454721 HDAC5; histone deacetylase 5
UBE2F GeneProduct ncbigene:460054 UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
BUB1B GeneProduct ncbigene:453324 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
ORC1L GeneProduct ncbigene:456857 ORC1L; origin recognition complex subunit 1-like (yeast)
MAD1L1 GeneProduct ncbigene:463223 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
PTTG2 GeneProduct ncbigene:736475 PTTG2; pituitary tumor-transforming
SMAD3 GeneProduct ncbigene:748161 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
CDC45L GeneProduct ncbigene:458651 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CCNE1 GeneProduct ncbigene:455914 CCNE1; cyclin E
CCNB3 GeneProduct ncbigene:465635 CCNB3; cyclin B
CCNA2 GeneProduct ncbigene:461467 CCNA2; cyclin A2
TFDP1 GeneProduct ncbigene:465967 TFDP1; transcription factor Dp-1
WEE1 GeneProduct ncbigene:466440 WEE1; WEE1+ homolog (S. pombe) [EC:]
CDK2 GeneProduct ncbigene:467032 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDH1 GeneProduct ncbigene:468009
CCND3 GeneProduct ncbigene:462689 CCND3; cyclin D3
TGFB1 GeneProduct ncbigene:456060
RBL1 GeneProduct ncbigene:735916 RBL1; retinoblastoma-like 1 (p107)
CDK4 GeneProduct ncbigene:452025 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDC25C GeneProduct ncbigene:746151 CDC25C; cell division cycle 25C [EC:]
CDC25A GeneProduct ncbigene:460341 CDC25A; cell division cycle 25A [EC:]
TP53 GeneProduct ncbigene:455214
ATM GeneProduct ncbigene:451530 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:]
ABL1 GeneProduct ncbigene:464802 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:
SKP2 GeneProduct ncbigene:471570 SKP2; S-phase kinase-associated protein 2 (p45
CDC6 GeneProduct ncbigene:468234 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
SKP2 GeneProduct ncbigene:471570 SKP2; S-phase kinase-associated protein 2 (p45
CCNA1 GeneProduct ncbigene:467260 CCNA1; cyclin A1
SMAD4 GeneProduct ncbigene:468537 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
CCNB1 GeneProduct ncbigene:461835 CCNB1; cyclin B1
CDKN1A GeneProduct ncbigene:747442
CDK2 GeneProduct ncbigene:467032 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
ATR GeneProduct ncbigene:460745 ATR; ataxia telangiectasia and Rad3 related
E2F4 GeneProduct ncbigene:454158 E2F4; E2F transcription factor 4 p107/p130-binding
LOC738624 GeneProduct ncbigene:738624 HDAC3; histone deacetylase 3
MCM6 GeneProduct ncbigene:741695 MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
CHEK1 GeneProduct ncbigene:739836 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
LOC462950 GeneProduct ncbigene:462950 HDAC2; histone deacetylase 2
MCM4 GeneProduct ncbigene:472757 MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
CCNA1 GeneProduct ncbigene:467260 CCNA1; cyclin A1
BUB1 GeneProduct ncbigene:459484 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
RB1 GeneProduct ncbigene:452715 RB1; retinoblastoma 1 (including osteosarcoma)
ORC5L GeneProduct ncbigene:463636 ORC5L; origin recognition complex subunit 5-like (yeast)
PKMYT1 GeneProduct ncbigene:467880 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
MCM2 GeneProduct ncbigene:460668 MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MAD2L2 GeneProduct ncbigene:457953 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
E2F2 GeneProduct ncbigene:469153 E2F2; E2F transcription factor 2
CDC2 GeneProduct ncbigene:450481 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
PLK1 GeneProduct ncbigene:453991 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
ORC2L GeneProduct ncbigene:459868 ORC2L; origin recognition complex subunit 2-like (yeast)
MCM5 GeneProduct ncbigene:458790 MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
DBF4 GeneProduct ncbigene:472668 ASK; activator of S phase kinas
GSK3B GeneProduct ncbigene:470896 GSK3B; glycogen synthase kinase 3 beta [EC:]
CDC2 GeneProduct ncbigene:450481 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
GADD45A GeneProduct ncbigene:456929
ORC6L GeneProduct ncbigene:465140 ORC6L; origin recognition complex subunit 6-like (yeast)
MCM3 GeneProduct ncbigene:462763 MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
CDC7 GeneProduct ncbigene:469380 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDC14B GeneProduct ncbigene:465251 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
E2F6 GeneProduct ncbigene:470148 E2F6; E2F transcription factor 6
PCNA GeneProduct ncbigene:458081 PCNA; proliferating cell nuclear antigen
E2F5 GeneProduct ncbigene:747256 E2F5; E2F transcription factor 5 p130-binding


  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia