Monoamine GPCRs (WP957)

Pan troglodytes

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Egon Willighagen , Kristina Hanspers , and Martina Summer-Kutmon


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Pan troglodytes



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.compound:9308
HRH1 GeneProduct ncbigene:470746
HTR4 GeneProduct ncbigene:462175
DRD3 GeneProduct ncbigene:470885
HRH2 GeneProduct ncbigene:471750
CHRM3 GeneProduct ncbigene:469725
DRD5 GeneProduct ncbigene:473340
DRD4 GeneProduct ncbigene:449578
ADRB3 GeneProduct ncbigene:464113
CHRM2 GeneProduct ncbigene:463758
HTR6 GeneProduct ncbigene:469199
HTR1D GeneProduct ncbigene:469219
CHRM1 GeneProduct ncbigene:451272
HTR1E GeneProduct ncbigene:472064
HTR7 GeneProduct ncbigene:466154
CHRM4 GeneProduct ncbigene:466504
DRD2 GeneProduct ncbigene:451553
CHRM5 GeneProduct ncbigene:503515
ADRA2A GeneProduct ncbigene:466201
HTR2A GeneProduct ncbigene:467355
HTR1F GeneProduct ncbigene:470863
HTR5A GeneProduct ncbigene:463837
ADRB1 GeneProduct ncbigene:466206
ADRA2B GeneProduct ncbigene:459410
HTR2C GeneProduct ncbigene:473740
HTR2B GeneProduct ncbigene:737647
HTR1A GeneProduct ncbigene:471533
ADRA1D GeneProduct ncbigene:469869
HTR1B GeneProduct ncbigene:462833
ADRB2 GeneProduct ncbigene:471690