Nuclear receptors (WP950)

Pan troglodytes

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])


Alex Pico , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Pan troglodytes



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact URI Comment
THRB GeneProduct ncbigene:470771
THRB GeneProduct ncbigene:470771
RARA GeneProduct ncbigene:454647
RARB GeneProduct ncbigene:745516
RARG GeneProduct ncbigene:451935
RARG GeneProduct ncbigene:451935
PPARA GeneProduct ncbigene:458910
PPARD GeneProduct ncbigene:463188
PPARG GeneProduct ncbigene:460178
PPARG GeneProduct ncbigene:460178
NR1D2 GeneProduct ncbigene:460230
NR0B1 GeneProduct ncbigene:450140
ROR1 GeneProduct ncbigene:456910
RORA GeneProduct ncbigene:747433
RORC GeneProduct ncbigene:457303
NR1H2 GeneProduct ncbigene:456227
NR1H3 GeneProduct ncbigene:466507
HNF4A GeneProduct ncbigene:458269
RXRA GeneProduct ncbigene:464834
RXRB GeneProduct ncbigene:462601
RXRG GeneProduct ncbigene:457476
NR2C2 GeneProduct ncbigene:460199
NR2F1 GeneProduct ncbigene:461753
NR2F2 GeneProduct ncbigene:467769
NR2F6 GeneProduct ncbigene:748739
NR2E1 GeneProduct ncbigene:472088
ESR1 GeneProduct ncbigene:463079
ESR2 GeneProduct ncbigene:452964
ESRRA GeneProduct ncbigene:466651
ESRRB GeneProduct ncbigene:453056
NR3C1 GeneProduct ncbigene:471681
PGR GeneProduct ncbigene:451502
AR GeneProduct ncbigene:747460
NR4A1 GeneProduct ncbigene:451913
NR4A2 GeneProduct ncbigene:459669
NR5A1 GeneProduct ncbigene:464724
NR5A2 GeneProduct ncbigene:469631
NR1I2 GeneProduct ncbigene:745458
NR1I3 GeneProduct ncbigene:458014


  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia