Wnt signaling pathway (WP899)

Pan troglodytes

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].


Thomas Kelder , Daniela Digles , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Pan troglodytes



Pathway Ontology

Wnt signaling pathway


Label Type Compact Identifier Comment
LDLR GeneProduct ncbigene:455722
WNT1 GeneProduct ncbigene:742674
WNT2 GeneProduct ncbigene:463673
WNT2B GeneProduct ncbigene:457103
WNT3 GeneProduct ncbigene:468297
WNT3A GeneProduct ncbigene:469698
WNT4 GeneProduct ncbigene:469212
WNT5B GeneProduct ncbigene:467191
WNT10A GeneProduct ncbigene:459952
WNT10B GeneProduct ncbigene:451870
WNT11 GeneProduct ncbigene:451431
WNT16 GeneProduct ncbigene:737375
WNT16 GeneProduct ncbigene:737375
FZD1 GeneProduct ncbigene:463524
FZD10 GeneProduct ncbigene:467160
FZD9 GeneProduct ncbigene:472405
FZD8 GeneProduct ncbigene:466040
FZD7 GeneProduct ncbigene:459881
FZD6 GeneProduct ncbigene:464327
FZD5 GeneProduct ncbigene:470627
SFRP4 GeneProduct ncbigene:463356
FZD3 GeneProduct ncbigene:472726
MAPK9 GeneProduct ncbigene:462336
MAPK10 GeneProduct ncbigene:461358
RHOA GeneProduct ncbigene:461014
DVL1 GeneProduct ncbigene:457191
DVL2 GeneProduct ncbigene:455236
DVL3 GeneProduct ncbigene:460882
PRKCG GeneProduct ncbigene:456276
PRKCI GeneProduct ncbigene:450143
PRKCH GeneProduct ncbigene:746068
PRKD1 GeneProduct ncbigene:452834
PRKCQ GeneProduct ncbigene:450288
PRKCZ GeneProduct ncbigene:743533
PPP2R5E GeneProduct ncbigene:452962
PPP2R5C GeneProduct ncbigene:453170
FRAT1 GeneProduct ncbigene:466169
AXIN1 GeneProduct ncbigene:453789
CSNK1E GeneProduct ncbigene:458829
GSK3B GeneProduct ncbigene:470896 MOUSE:KG38 MOUSE
APC GeneProduct ncbigene:461999
CTNNB1 GeneProduct ncbigene:450183
FBXW2 GeneProduct ncbigene:464698
PAFAH1B1 GeneProduct ncbigene:454422
MYC GeneProduct ncbigene:464393
CCND1 GeneProduct ncbigene:747688
CCND2 GeneProduct ncbigene:747123
CCND3 GeneProduct ncbigene:462689
FOSL1 GeneProduct ncbigene:745919
JUN GeneProduct ncbigene:456893
PLAU GeneProduct ncbigene:738078
PRKCA GeneProduct ncbigene:454832


  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia