Adipogenesis (WP869)

Pan troglodytes

The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.


Kristina Hanspers , Martijn Van Iersel , and Martina Summer-Kutmon


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Pan troglodytes



Pathway Ontology

signaling pathway pertinent to development


Label Type Compact URI Comment
IGF1 GeneProduct ncbigene:741055
PTGIS GeneProduct ncbigene:458323
PPARD GeneProduct ncbigene:463188
CREB1 GeneProduct ncbigene:459901
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DDIT3 GeneProduct ncbigene:452017
LIF GeneProduct ncbigene:736309
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LOC450614 GeneProduct ncbigene:450614
LOC738157 GeneProduct ncbigene:738157
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RARA GeneProduct ncbigene:454647
NR1H3 GeneProduct ncbigene:466507
LPL GeneProduct ncbigene:464031
SREBF1 GeneProduct ncbigene:454480
FAS GeneProduct ncbigene:738331
RBL1 GeneProduct ncbigene:735916
GATA3 GeneProduct ncbigene:450296
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MEF2D GeneProduct ncbigene:457396
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MIF GeneProduct ncbigene:748716
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SERPINE1 GeneProduct ncbigene:472467
SLC2A4 GeneProduct ncbigene:468443
SCD GeneProduct ncbigene:450676
TWIST1 GeneProduct ncbigene:450135
LEP GeneProduct ncbigene:449638
RETN GeneProduct ncbigene:742100
CFD GeneProduct ncbigene:455533
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RBL2 GeneProduct ncbigene:467978
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ADFP GeneProduct ncbigene:465012
AGT GeneProduct ncbigene:450104
CDKN1A GeneProduct ncbigene:747442
SP1 GeneProduct ncbigene:451939
HMGA1 GeneProduct ncbigene:746594
PLIN GeneProduct ncbigene:467755
IL6 GeneProduct ncbigene:463288
GADD45A GeneProduct ncbigene:456929
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CEBPD GeneProduct ncbigene:464163
BMP1 GeneProduct ncbigene:464042
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BMP3 GeneProduct ncbigene:471189
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NDN GeneProduct ncbigene:453273
FOXO1 GeneProduct ncbigene:467352
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NCOA1 GeneProduct ncbigene:459068
NCOA2 GeneProduct ncbigene:464226
PPARA GeneProduct ncbigene:458910
STAT3 GeneProduct ncbigene:454682
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STAT1 GeneProduct ncbigene:459834
STAT6 GeneProduct ncbigene:452005
SOCS1 GeneProduct ncbigene:737070
SOCS3 GeneProduct ncbigene:454921
LIFR GeneProduct ncbigene:738797
IL6ST GeneProduct ncbigene:461866
MBNL1 GeneProduct ncbigene:460787
OSM GeneProduct ncbigene:736338
CTNNB1 GeneProduct ncbigene:450183
UCP1 GeneProduct ncbigene:461504
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WNT1 GeneProduct ncbigene:742674
SMAD3 GeneProduct ncbigene:748161
FZD1 GeneProduct ncbigene:463524
DVL1 GeneProduct ncbigene:457191
HNF1A GeneProduct ncbigene:744121
RXRG GeneProduct ncbigene:457476
FRZB GeneProduct ncbigene:742552
INS GeneProduct ncbigene:449570
NAMPT GeneProduct ncbigene:463648
SPOCK1 GeneProduct ncbigene:462085
TRIB3 GeneProduct ncbigene:745623
GATA4 GeneProduct ncbigene:472698
NR2F1 GeneProduct ncbigene:461753
NRIP1 GeneProduct ncbigene:474071
RORA GeneProduct ncbigene:747433
PRLR GeneProduct ncbigene:461925
PNPLA3 GeneProduct ncbigene:458896
HIF1A GeneProduct ncbigene:746195
KLF6 GeneProduct ncbigene:450269
KLF7 GeneProduct ncbigene:459900
SFRP4 GeneProduct ncbigene:463356
NCOR1 GeneProduct ncbigene:741384
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EGR2 GeneProduct ncbigene:745846
EBF1 GeneProduct ncbigene:462229
EPAS1 GeneProduct ncbigene:459204
AHR GeneProduct ncbigene:463278
CISD1 GeneProduct ncbigene:450472
GDF10 GeneProduct ncbigene:735795
IRS1 GeneProduct ncbigene:459985
BSCL2 GeneProduct ncbigene:451262
LMNA GeneProduct ncbigene:457385
AGPAT2 GeneProduct ncbigene:748669
ZMPSTE24 GeneProduct ncbigene:456790
LPIN1 GeneProduct ncbigene:459036
LPIN2 GeneProduct ncbigene:455317
PCK1 GeneProduct ncbigene:458362
PCK2 GeneProduct ncbigene:452807
IRS2 GeneProduct ncbigene:452657
E2F4 GeneProduct ncbigene:454158


  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia