Cell cycle (WP844)

Gallus gallus

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(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Authors

Martijn Van Iersel , Martina Summer-Kutmon , and Lauren J. Dupuis

Activity

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

cell cycle pathway

Participants

Label Type Compact URI Comment
PTTG1 GeneProduct ncbigene:416158 PTTG1; pituitary tumor-transforming
CDKN2A GeneProduct ncbigene:395077
RCJMB04_5e12 GeneProduct ncbigene:427820 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
CDK6 GeneProduct ncbigene:420558 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CCNA2 GeneProduct ncbigene:396172 CCNA2; cyclin A2
CDC20 GeneProduct ncbigene:424563 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CCNE2 GeneProduct ncbigene:420231 CCNE2; cyclin E
ORC4L GeneProduct ncbigene:424307 ORC4L; origin recognition complex subunit 4-like (yeast)
RB1 GeneProduct ncbigene:386582 RB1; retinoblastoma 1 (including osteosarcoma)
TBC1D8 GeneProduct ncbigene:428012
HDAC4 GeneProduct ncbigene:374207 HDAC4; histone deacetylase 4
CCND2 GeneProduct ncbigene:374047 CCND2; cyclin D2
PRKDC GeneProduct ncbigene:395376 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
EP300 GeneProduct ncbigene:418000 EP300; E1A binding protein p300
ORC3L GeneProduct ncbigene:421822 ORC3L; origin recognition complex subunit 3-like (yeast)
BUB3 GeneProduct ncbigene:423949 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CHEK2 GeneProduct ncbigene:768913 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HDAC7A GeneProduct ncbigene:426885 HDAC7A; histone deacetylase 7
RB1 GeneProduct ncbigene:386582 RB1; retinoblastoma 1 (including osteosarcoma)
MDM2 GeneProduct ncbigene:395609 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
CDC14A GeneProduct ncbigene:424466 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
HDAC8 GeneProduct ncbigene:422182 HDAC8; histone deacetylase
CCNH GeneProduct ncbigene:427328 CCNH; cyclin H
ESPL1 GeneProduct ncbigene:425536 ESPL1; extra spindle poles like 1 (S. cerevisiae
HDAC1 GeneProduct ncbigene:373961 HDAC1; histone deacetylase 1
CDKN1B GeneProduct ncbigene:769872 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
RBL1 GeneProduct ncbigene:419126
MAD2L1 GeneProduct ncbigene:422675 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CCNB2 GeneProduct ncbigene:415400 CCNB2; cyclin B2
UBE2F GeneProduct ncbigene:424015 UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
BUB1B GeneProduct ncbigene:378922 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
ORC1L GeneProduct ncbigene:424640 ORC1L; origin recognition complex subunit 1-like (yeast)
MAD1L1 GeneProduct ncbigene:427658 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
SMAD3 GeneProduct ncbigene:395132 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
CDC45L GeneProduct ncbigene:416776 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CCNE1 GeneProduct ncbigene:426117 CCNE1; cyclin E
CCNA2 GeneProduct ncbigene:396172 CCNA2; cyclin A2
TFDP1 GeneProduct ncbigene:418739 TFDP1; transcription factor Dp-1
E2F3 GeneProduct ncbigene:420824 E2F3; E2F transcription factor 3
WEE1 GeneProduct ncbigene:423045 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
CDH1 GeneProduct ncbigene:415860
CCND3 GeneProduct ncbigene:419928 CCND3; cyclin D3
RBL1 GeneProduct ncbigene:419126 RBL1; retinoblastoma-like 1 (p107)
CDC25A GeneProduct ncbigene:420375 CDC25A; cell division cycle 25A [EC:3.1.3.48]
TP53 GeneProduct ncbigene:396200
ATM GeneProduct ncbigene:395401 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ABL1 GeneProduct ncbigene:417181 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
SKP2 GeneProduct ncbigene:427437 SKP2; S-phase kinase-associated protein 2 (p45
SKP2 GeneProduct ncbigene:427437 SKP2; S-phase kinase-associated protein 2 (p45
CCNA1 GeneProduct ncbigene:418901 CCNA1; cyclin A1
E2F1 GeneProduct ncbigene:396142 E2F1; E2F transcription factor 1
ATR GeneProduct ncbigene:424777 ATR; ataxia telangiectasia and Rad3 related
E2F4 GeneProduct ncbigene:769430 E2F4; E2F transcription factor 4 p107/p130-binding
HDAC3 GeneProduct ncbigene:395506 HDAC3; histone deacetylase 3
MCM6 GeneProduct ncbigene:424295 MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
HDAC2 GeneProduct ncbigene:395635 HDAC2; histone deacetylase 2
MCM4 GeneProduct ncbigene:426764 MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
CCNA1 GeneProduct ncbigene:418901 CCNA1; cyclin A1
BUB1 GeneProduct ncbigene:421226 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
RB1 GeneProduct ncbigene:386582 RB1; retinoblastoma 1 (including osteosarcoma)
ORC5L GeneProduct ncbigene:417714 ORC5L; origin recognition complex subunit 5-like (yeast)
MCM2 GeneProduct ncbigene:416027 MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MAD2L2 GeneProduct ncbigene:419493 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
CDC2 GeneProduct ncbigene:396252 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
PLK1 GeneProduct ncbigene:416575 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
ORC2L GeneProduct ncbigene:424077 ORC2L; origin recognition complex subunit 2-like (yeast)
MCM5 GeneProduct ncbigene:418058 MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
DBF4 GeneProduct ncbigene:420536 ASK; activator of S phase kinas
GSK3B GeneProduct ncbigene:418335 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
CDC2 GeneProduct ncbigene:396252 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
GADD45A GeneProduct ncbigene:693255
ORC6L GeneProduct ncbigene:415749 ORC6L; origin recognition complex subunit 6-like (yeast)
MCM3 GeneProduct ncbigene:422043 MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
CDC7 GeneProduct ncbigene:424507 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDC14C GeneProduct ncbigene:427473 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
PCNA GeneProduct ncbigene:373984 PCNA; proliferating cell nuclear antigen
RCJMB04_30p22 GeneProduct ncbigene:420206 E2F5; E2F transcription factor 5 p130-binding

References

  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia