G1 to S cell cycle control (WP840)

Gallus gallus

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Authors

Kristina Hanspers , Christine Chichester , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

G1/S DNA damage checkpoint pathway cell cycle checkpoint pathway

Participants

Label Type Compact URI Comment
RB1 GeneProduct ensembl:ENSGALG00000016997 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5925
E2F1 GeneProduct ensembl:ENSGALG00000003045 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1869
POLE GeneProduct ensembl:ENSGALG00000039384 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5426
CDKN1B GeneProduct ensembl:ENSGALG00000022980 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1027
CDK6 GeneProduct ensembl:ENSGALG00000009476 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1021
PCNA GeneProduct ensembl:ENSGALG00000029292 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5111
CDKN1A GeneProduct ensembl:ENSGALG00000028318 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1026
CDC45 GeneProduct ensembl:ENSGALG00000001616 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8318
CDKN2A GeneProduct ensembl:ENSGALG00000026137 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1029
CDK1 GeneProduct ensembl:ENSGALG00000003085 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:983
PRIM2 GeneProduct ensembl:ENSGALG00000016278 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5558
CCND2 GeneProduct ensembl:ENSGALG00000017283 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:894
E2F5 GeneProduct ensembl:ENSGALG00000038915 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1875
CCNE1 GeneProduct ensembl:ENSGALG00000004494 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:898
CDKN2B GeneProduct ensembl:ENSGALG00000026137 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1030
MDM2 GeneProduct ensembl:ENSGALG00000009942 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4193
CDK7 GeneProduct ensembl:ENSGALG00000014790 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1022
CCNG2 GeneProduct ensembl:ENSGALG00000010347 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:901
RPA2 GeneProduct ensembl:ENSGALG00000000734 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6118
CDK2 GeneProduct ensembl:ENSGALG00000032699 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1017
E2F4 GeneProduct ensembl:ENSGALG00000001722 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1874
CDK7 GeneProduct ensembl:ENSGALG00000014790 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1022
CREB3 GeneProduct ensembl:ENSGALG00000002523 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10488
CREB3L3 GeneProduct ensembl:ENSGALG00000001252 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:84699
MYT1 GeneProduct ensembl:ENSGALG00000005932 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4661
TFDP2 GeneProduct ensembl:ENSGALG00000025759 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7029
RB1 GeneProduct ensembl:ENSGALG00000016997 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5925
CCND3 GeneProduct ensembl:ENSGALG00000003485 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:896
CCND1 GeneProduct ensembl:ENSGALG00000007555 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:595
CCNH GeneProduct ensembl:ENSGALG00000015641 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:902
MYC GeneProduct ensembl:ENSGALG00000033631 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
RPA3 GeneProduct ensembl:ENSGALG00000010700 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6119
MCM4 GeneProduct ensembl:ENSGALG00000012915 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4173
MCM3 GeneProduct ensembl:ENSGALG00000016676 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4172
ORC1 GeneProduct ensembl:ENSGALG00000010623 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4998
RB1 GeneProduct ensembl:ENSGALG00000016997 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5925
MCM6 GeneProduct ensembl:ENSGALG00000012348 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4175
MCM2 GeneProduct ensembl:ENSGALG00000006037 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4171
ORC3 GeneProduct ensembl:ENSGALG00000015800 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23595
CDKN2C GeneProduct ensembl:ENSGALG00000010537 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1031
POLE2 GeneProduct ensembl:ENSGALG00000012237 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5427
MNAT1 GeneProduct ensembl:ENSGALG00000011910 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4331
ORC6 GeneProduct ensembl:ENSGALG00000004342 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23594
CDK2 GeneProduct ensembl:ENSGALG00000032699 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1017
MCM5 GeneProduct ensembl:ENSGALG00000012546 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4174
E2F6 GeneProduct ensembl:ENSGALG00000016454 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1876
ORC2 GeneProduct ensembl:ENSGALG00000008234 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4999
E2F3 GeneProduct ensembl:ENSGALG00000012680 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1871
TFDP1 GeneProduct ensembl:ENSGALG00000016823 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7027
CDK6 GeneProduct ensembl:ENSGALG00000009476 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1021
RPA1 GeneProduct ensembl:ENSGALG00000003072 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6117
CREB1 GeneProduct ensembl:ENSGALG00000041244 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1385
RBL1 GeneProduct ensembl:ENSGALG00000001332 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5933
TFDP1 GeneProduct ensembl:ENSGALG00000016823 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7027
WEE1 GeneProduct ensembl:ENSGALG00000005769 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7465
ATM GeneProduct ensembl:ENSGALG00000017159 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:472
CREB3L1 GeneProduct ensembl:ENSGALG00000008393 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:90993
GADD45A GeneProduct ensembl:ENSGALG00000025977 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1647
POLA2 GeneProduct ensembl:ENSGALG00000030099 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23649
ORC4 GeneProduct ensembl:ENSGALG00000012448 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5000
CCNE1 GeneProduct ensembl:ENSGALG00000004494 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:898
PRIM1 GeneProduct ensembl:ENSGALG00000041973 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5557
CDC25A GeneProduct ensembl:ENSGALG00000038469 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:993
CCNE1 GeneProduct ensembl:ENSGALG00000004494 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:898
CCNA1 GeneProduct ensembl:ENSGALG00000017052 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8900
ORC5 GeneProduct ensembl:ENSGALG00000008175 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5001
CCNE2 GeneProduct ensembl:ENSGALG00000040794 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9134

References

  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia