Monoamine GPCRs (WP839)

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G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Egon Willighagen and Kristina Hanspers


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Label Type Compact Identifier Comment
Serotonin Metabolite chebi:28790
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.substance:9676
Histamine Metabolite chebi:18295
Dopamine Metabolite chebi:18243
ADRA2C GeneProduct ncbigene:428799
HTR4 GeneProduct ncbigene:416150
DRD3 GeneProduct ncbigene:770757
HRH2 GeneProduct ncbigene:427635
CHRM3 GeneProduct ncbigene:396364
ADRA1A GeneProduct ncbigene:428203
DRD5 GeneProduct ncbigene:428795
DRD4 GeneProduct ncbigene:423016
ADRA1B GeneProduct ncbigene:373890
CHRM2 GeneProduct ncbigene:418126
HTR6 GeneProduct ncbigene:430019
HTR1D GeneProduct ncbigene:769107
HTR1E GeneProduct ncbigene:771973
HTR7 GeneProduct ncbigene:423794
CHRM4 GeneProduct ncbigene:423195
DRD2 GeneProduct ncbigene:428252
CHRM5 GeneProduct ncbigene:428881
ADRA2A GeneProduct ncbigene:428980
HTR2A GeneProduct ncbigene:428070
HTR1F GeneProduct ncbigene:427963
DRD1 GeneProduct ncbigene:427633
HTR5A GeneProduct ncbigene:428409
ADRB1 GeneProduct ncbigene:430991
ADRA2B GeneProduct ncbigene:427631
HTR2C GeneProduct ncbigene:428707
HTR2B GeneProduct ncbigene:395581
HTR1A GeneProduct ncbigene:431581
ADRA1D GeneProduct ncbigene:422933
HTR1B GeneProduct ncbigene:421858
ADRB2 GeneProduct ncbigene:427623