Integrin-mediated cell adhesion (WP832)

Gallus gallus

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]

Authors

Thomas Kelder , Daniela Digles , and Lauren J. Dupuis

Activity

last edited

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Cited In

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
ITGA4 GeneProduct ncbigene:424121
CAPN9 GeneProduct ncbigene:421544 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
ILK GeneProduct ncbigene:374018 ILK; integrin-linked kinase [EC:2.7.1.-]
PTK2 GeneProduct ncbigene:396416 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
ITGB3 GeneProduct ncbigene:374209
SOS1 GeneProduct ncbigene:425964 SOS1; son of sevenless homolog 1 (Drosophila)
ZYX GeneProduct ncbigene:418300 ZYX; zyxin
RAP1A GeneProduct ncbigene:419867 RAP1A; RAP1A member of RAS oncogene family
CRK GeneProduct ncbigene:417553 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CAPN5 GeneProduct ncbigene:419086 CAPN5; calpain
SEPP1 GeneProduct ncbigene:431587 SEPP1; selenoprotein P plasma
ROCK1 GeneProduct ncbigene:373970 ROCK1; Rho-associated coiled-coil containing protein kinase
ITGAV GeneProduct ncbigene:396420
ITGA3 GeneProduct ncbigene:373946
VCL GeneProduct ncbigene:396422 VCL; vinculin
RAPGEF1 GeneProduct ncbigene:417173 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
CAPN6 GeneProduct ncbigene:422341 CAPN6; calpain 6 [EC:3.4.22.17]
RAC2 GeneProduct ncbigene:418044 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
PXN GeneProduct ncbigene:395832 PXN; paxillin
PAK6 GeneProduct ncbigene:428837 PAK6; p21(CDKN1A)-activated kinase
MAP2K1 GeneProduct ncbigene:415549 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
BCAR1 GeneProduct ncbigene:415691 BCAR1; breast cancer anti-estrogen resistance 1
ITGB4 GeneProduct ncbigene:417374
ITGB8 GeneProduct ncbigene:420605
PDPK1 GeneProduct ncbigene:416588 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
CAPN3 GeneProduct ncbigene:423233 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
SRC GeneProduct ncbigene:396442 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
DOCK1 GeneProduct ncbigene:423960 DOCK1; dedicator of cyto-kinesis
VAV3 GeneProduct ncbigene:373939 VAV3; vav 3 oncogene
BRAF GeneProduct ncbigene:396239 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAV2 GeneProduct ncbigene:417772 CAV2; caveolin 2
CAPN10 GeneProduct ncbigene:424945 CAPN10; calpain 10 [EC:3.4.22.17
ITGA1 GeneProduct ncbigene:395951
FYN GeneProduct ncbigene:396294 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
MAPK10 GeneProduct ncbigene:422592
CSK GeneProduct ncbigene:396396 CSK; c-src tyrosine kinase [EC:2.7.1.112]
CAV3 GeneProduct ncbigene:378796 CAV3; caveolin 3
RHO GeneProduct ncbigene:396486 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
HRAS GeneProduct ncbigene:396229
CAV1 GeneProduct ncbigene:373996 CAV1; caveolin 1 caveolae protein 22kD
ITGB6 GeneProduct ncbigene:424191
RCJMB04_5i17 GeneProduct ncbigene:415419 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
SHC1 GeneProduct ncbigene:395934 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
ITGB1 GeneProduct ncbigene:374058
CAPN2 GeneProduct ncbigene:395963 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
AKT3 GeneProduct ncbigene:421497 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:396349 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
PIK3R2 GeneProduct ncbigene:771142 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ITGA9 GeneProduct ncbigene:420757
TNS1 GeneProduct ncbigene:396439 TNS; tensi
CAPN7 GeneProduct ncbigene:420683 CAPN7; calpain 7 [EC:3.4.22.17
ITGA5 GeneProduct ncbigene:378932
RAF1 GeneProduct ncbigene:396245 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
VAV2 GeneProduct ncbigene:373938 VAV2; vav 2 oncogene
CDC42 GeneProduct ncbigene:395917 CDC42; cell division cycle 42 (GTP binding protein 25kD)
RCJMB04_36h7 GeneProduct ncbigene:415557 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
CAPNS1 GeneProduct ncbigene:770982 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
ITGB2 GeneProduct ncbigene:396181
PAK2 GeneProduct ncbigene:424860 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
RCJMB04_8f10 GeneProduct ncbigene:416496 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAPK1 GeneProduct ncbigene:373953 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
SORBS1 GeneProduct ncbigene:423749 SH3D5; SH3-domain protein 5 (ponsin
RAP1B GeneProduct ncbigene:417840 RAP1B; RAP1B member of RAS oncogene family
SRC GeneProduct ncbigene:396442 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
PAK3 GeneProduct ncbigene:422342 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
AKT2 GeneProduct ncbigene:373973 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:396240 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
RAC1 GeneProduct ncbigene:395871 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
ROCK2 GeneProduct ncbigene:374182 ROCK2; Rho-associated coiled-coil containing protein kinase
GIT2 GeneProduct ncbigene:374035 GIT2; G protein-coupled receptor kinase-interactor 2
ITGA6 GeneProduct ncbigene:396226
PAK1 GeneProduct ncbigene:419083 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
AKT1 GeneProduct ncbigene:395928 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
GRB2 GeneProduct ncbigene:386572 GRB2; growth factor receptor-bound protein 2
ITGB5 GeneProduct ncbigene:395142
ITGA8 GeneProduct ncbigene:396225
ITGA11 GeneProduct ncbigene:415560
ARHGEF7 GeneProduct ncbigene:418761 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
MYLK2 GeneProduct ncbigene:396356 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
PAK4 GeneProduct ncbigene:770462 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
MAPK12 GeneProduct ncbigene:769763 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
RAC3 GeneProduct ncbigene:395870 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
TLN1 GeneProduct ncbigene:395194 TLN1; talin 1
SHC3 GeneProduct ncbigene:431265 SHC3; neuronal Sh
PTK2 GeneProduct ncbigene:396416 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia