Leptin and adiponectin (WP683)

Mus musculus

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].


Thomas Kelder and Egon Willighagen


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Mus musculus



Disease Ontology

glucose metabolism disease

Pathway Ontology

leptin system pathway adiponectin signaling pathway


Label Type Compact URI Comment
Fatty acid Metabolite chebi:35366
Fatty acid Metabolite chebi:35366
Acetyl-CoA Metabolite chebi:15351
Malonyl-CoA Metabolite chebi:15531
Adipor1 GeneProduct ncbigene:72674
Prkaa1 GeneProduct ncbigene:105787
Prkab1 GeneProduct ncbigene:19079
Leptin GeneProduct ncbigene:16846
Adipor2 GeneProduct ncbigene:68465
Acc1 GeneProduct ncbigene:107476
Prkag1 GeneProduct ncbigene:19082
Lepr GeneProduct ncbigene:16847
Cpt1 GeneProduct ncbigene:12894
Adiponectin GeneProduct ncbigene:11450


  1. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Dyck DJ, Heigenhauser GJF, Bruce CR. Acta Physiol (Oxf). 2006 Jan;186(1):5–16. PubMed Europe PMC Scholia