p53 signal pathway (WP656)

Rattus norvegicus

We've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918


Emmaverver , Kristina Hanspers , Thomas Kelder , Jinggao , Daniela Digles , and Martina Summer-Kutmon


last edited

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Rattus norvegicus



Pathway Ontology

p53-independent G1/S DNA damage checkpoint pathway


Label Type Compact URI Comment
Dexamethazone Metabolite hmdb:HMDB0015364
Phenobarbital Metabolite hmdb:HMDB0015305
Cytochrome C1 Metabolite chebi:4067
p21 GeneProduct ncbigene:24525
Casp3 GeneProduct ensembl:ENSRNOG00000010475
Scotin GeneProduct ensembl:ENSRNOG00000020667
Ei24 GeneProduct ensembl:ENSRNOG00000030391
Bax GeneProduct ensembl:ENSRNOG00000020876
Cyclin D GeneProduct uniprot:P48961
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
Gtse1 GeneProduct ensembl:ENSRNOG00000016148
Casp9 GeneProduct ensembl:ENSRNOG00000012944
Bid GeneProduct ensembl:ENSRNOG00000012439
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
Sfn GeneProduct ensembl:ENSRNOG00000033153
Casp8 GeneProduct ensembl:ENSRNOG00000012331
Igf1 GeneProduct ensembl:ENSRNOG00000004517
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
Zmat3 GeneProduct ensembl:ENSRNOG00000010119
Igfbp3 GeneProduct ensembl:ENSRNOG00000061910
Reprimo GeneProduct ensembl:ENSRNOG00000005109
Apaf 1 GeneProduct ensembl:ENSRNOG00000008022
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Cdc2 GeneProduct ensembl:ENSRNOG00000000632
Parp1 GeneProduct ensembl:ENSRNOG00000003084
Cyclin B3 GeneProduct ensembl:ENSRNOG00000002951
Noxa GeneProduct ensembl:ENSRNOG00000018770
Gadd45 GeneProduct ensembl:ENSRNOG00000013090
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Puma GeneProduct uniprot:Q80ZG6
Perp GeneProduct ensembl:ENSRNOG00000011994
Fas GeneProduct ensembl:ENSRNOG00000019142
Siah GeneProduct ensembl:ENSRNOG00000015143
Cyclin E GeneProduct ensembl:ENSRNOG00000014786


  1. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. Malanga M, Pleschke JM, Kleczkowska HE, Althaus FR. J Biol Chem. 1998 May 8;273(19):11839–43. PubMed Europe PMC Scholia
  2. Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression. Simbulan-Rosenthal CM, Rosenthal DS, Ding R, Bhatia K, Smulson ME. Biochem Biophys Res Commun. 1998 Dec 30;253(3):864–8. PubMed Europe PMC Scholia
  3. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD. Toxicol Sci. 2006 Dec;94(2):272–80. PubMed Europe PMC Scholia