Cholesterol metabolism (WP632)

Rattus norvegicus

Cholesterol is essential for life - it's a required for the regulation of membrane fluidity. Cholesterol also serves as a precursor for many other biochemical pathways. Cholesterol is synthesized throughout the body but mainly in liver, intestines, adrenal glands and reproductive organs. Synthesis starts with the combination of Acetyl-CoA and Acetoacetyl-CoA. An important intemediary in the synthesis of cholesterol is mevalonate. Synthesis of cholesterol is regulated by a homeostatic mechanism.


Susan Coort , I450472 , Kristina Hanspers , Martina Summer-Kutmon , Christine Chichester , and Egon Willighagen


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Rattus norvegicus



Pathway Ontology

cholesterol metabolic pathway arterial occlusive disease pathway


Label Type Compact URI Comment
(S)-2,3-Epoxysqualene Metabolite hmdb:HMDB0001188
Isopentenyl pyrophosphate Metabolite hmdb:HMDB0001347
Lathosterol Metabolite hmdb:HMDB0001170
Dimethylallylpyrophosphate Metabolite hmdb:HMDB0001120
Mevalonate Metabolite hmdb:HMDB0000227
Squalene Metabolite hmdb:HMDB0000256
Lanosterin Metabolite hmdb:HMDB0001251
Acetoacetyl-CoA Metabolite hmdb:HMDB0001484
Mevalonate Pyrophosphat Metabolite hmdb:HMDB0001981
Cholesterol Metabolite hmdb:HMDB0000067
Geranyl pyrophosphate Metabolite hmdb:HMDB0001285
Dehydrocholesterol Metabolite hmdb:HMDB0000032
HMG-CoA Metabolite hmdb:HMDB0001375
Cholesterol ester Metabolite chebi:17002
Cholesterol Metabolite hmdb:HMDB0000067
Acetyl-CoA Metabolite hmdb:HMDB0001206
Farnesyl pyrophosphate Metabolite hmdb:HMDB0000961
Hmgcs1 GeneProduct ncbigene:29637
Soat1 GeneProduct ensembl:ENSRNOG00000004111
Scarb1 GeneProduct ensembl:ENSRNOG00000000981
Fdft1 GeneProduct ensembl:ENSRNOG00000021314
Hmgcr GeneProduct ncbigene:25675
Apoe GeneProduct ensembl:ENSRNOG00000018454
MVK GeneProduct ncbigene:81727
Dhcr7 GeneProduct ensembl:ENSRNOG00000020776
Srebf1 GeneProduct ensembl:ENSRNOG00000003463
Apoc2 GeneProduct ensembl:ENSRNOG00000018402
Lss GeneProduct ensembl:ENSRNOG00000054549
Fdps GeneProduct ncbigene:83791
Sqle GeneProduct ensembl:ENSRNOG00000009550
Ldlr GeneProduct ensembl:ENSRNOG00000009946
Lpl GeneProduct ensembl:ENSRNOG00000012181
Lipc GeneProduct ensembl:ENSRNOG00000060338
Apoc1 GeneProduct ensembl:ENSRNOG00000018426
Mvd GeneProduct ensembl:ENSRNOG00000013376
Nsdhl GeneProduct ensembl:ENSRNOG00000057814
Idi1 GeneProduct ensembl:ENSRNOG00000016690
Sc4mol GeneProduct ensembl:ENSRNOG00000032297
Lrp1 GeneProduct ncbigene:299858
Sc5d GeneProduct ensembl:ENSRNOG00000008305


  1. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB. EMBO J. 1997 Dec 15;16(24):7250–60. PubMed Europe PMC Scholia
  2. Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors. Wassmann S, Nickenig G. Drug News Perspect. 2002 Mar;15(2):85–92. PubMed Europe PMC Scholia