Monoamine GPCRs (WP570)

Mus musculus

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Nathan Salomonis , Joanna S. Fong , Sr Harsha.P , Sravanthi Sinha , Egon Willighagen , Daniela Digles , Martina Summer-Kutmon , and Kristina Hanspers


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Mus musculus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.compound:9308
Histamine Metabolite hmdb:HMDB0000870
Dopamine Metabolite hmdb:HMDB0000073
Hrh1 GeneProduct ncbigene:15465
Adra2c GeneProduct ncbigene:11553
Htr4 GeneProduct ncbigene:15562
Drd3 GeneProduct ncbigene:13490
Hrh2 GeneProduct ncbigene:15466
Chrm3 GeneProduct ncbigene:12671
Adra1a GeneProduct ncbigene:11549
Drd5 GeneProduct ncbigene:13492
Htr5b GeneProduct ncbigene:15564
Drd4 GeneProduct ncbigene:13491
Adrb3 GeneProduct ncbigene:11556
Adra1b GeneProduct ncbigene:11548
Chrm2 GeneProduct ncbigene:243764
Htr6 GeneProduct ncbigene:15565
Htr1d GeneProduct ncbigene:15552
Chrm1 GeneProduct ncbigene:12669
Htr7 GeneProduct ncbigene:15566
Chrm4 GeneProduct ncbigene:12672
Drd2 GeneProduct ncbigene:13489
Chrm5 GeneProduct ncbigene:213788
Adra2a GeneProduct ncbigene:11551
Htr2a GeneProduct ncbigene:15558
Htr1f GeneProduct ncbigene:15557
Drd1a GeneProduct ncbigene:13488
Htr5a GeneProduct ncbigene:15563
Adrb1 GeneProduct ncbigene:11554
Adra2b GeneProduct ncbigene:11552
Htr2c GeneProduct ncbigene:15560
Htr2b GeneProduct ncbigene:15559
Htr1a GeneProduct ncbigene:15550
Adra1d GeneProduct ncbigene:11550
Htr1b GeneProduct ncbigene:15551
Adrb2 GeneProduct ncbigene:11555