Parthanatos cell death signaling pathway (WP5585)

Homo sapiens

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This is pathway is an illustration for pathanatos. Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA leads to over-activation of poly(ADP-ribose) polymerase (PARP). PARP then generates the formation of large poly(ADP-ribose) polymers that induce the release of apoptosis-inducing factor from the outer mitochondrial membrane.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Yuanyuan Duan , Alex Pico , Egon Willighagen , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cell death pathway regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Nicotinamide adenine dinucleotide(NAD+) Metabolite chebi:15846
superoxide anion radical Metabolite chebi:18421
Double-stranded DNA Metabolite chebi:4705
ADP-riboses Metabolite chebi:16960
ROS Metabolite chebi:70982
NO Metabolite chebi:16480
ONOO- Metabolite chebi:25941
MIF GeneProduct ncbigene:4282
PARP1 GeneProduct ensembl:ENSG00000143799
AIFM1 GeneProduct ensembl:ENSG00000156709

References

  1. Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage. Zhang J, Pieper A, Snyder SH. J Neurochem. 1995 Sep;65(3):1411–4. PubMed Europe PMC Scholia
  2. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Zhang J, Dawson VL, Dawson TM, Snyder SH. Science. 1994 Feb 4;263(5147):687–9. PubMed Europe PMC Scholia
  3. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Beckman JS, Koppenol WH. Am J Physiol. 1996 Nov;271(5 Pt 1):C1424-37. PubMed Europe PMC Scholia
  4. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. Eliasson MJ, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, et al. J Neurosci. 1999 Jul 15;19(14):5910–8. PubMed Europe PMC Scholia
  5. Detection of peroxynitrite-induced protein and DNA modifications. Lorch S, Lightfoot R, Ohshima H, Virág L, Chen Q, Hertkorn C, et al. Methods Mol Biol. 2002;196:247–75. PubMed Europe PMC Scholia
  6. Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, et al. Sci Signal. 2011 Apr 5;4(167):ra20. PubMed Europe PMC Scholia
  7. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, et al. Science. 2016 Oct 7;354(6308):aad6872. PubMed Europe PMC Scholia
  8. Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases. Park H, Kam TI, Dawson TM, Dawson VL. Int Rev Cell Mol Biol. 2020;353:1–29. PubMed Europe PMC Scholia