Signaling lipids (WP5584)
Homo sapiens
Signaling lipids (SLs) play a crucial role in various signaling pathways, featuring diverse lipid backbone structures. Emerging evidence showing the biological significance and biomedical values of SLs has strongly spurred the advancement of analytical approaches aimed at profiling SLs.The platform enables analyses of 260 metabolites covering oxylipins (isoprostanes, prostaglandins and other oxidized lipids), free fatty acids, lysophospholipids, sphingoid bases (C16, C18), platelet activating factors (C16, C18), endocannabinoids and bile acids
For a description of pathway objects, see the WikiPathways Legend.
Authors
Lu and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
glycerophospholipid metabolic pathway fatty acid metabolic pathway eicosanoid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PA | Metabolite | lipidmaps:LMGP10010000 | |
| LPA C14:0 | Metabolite | lipidmaps:LMGP10050007 | |
| LPA C16:0 | Metabolite | lipidmaps:LMGP10050006 | |
| LPA C16:1 | Metabolite | lipidmaps:LMGP10050016 | |
| LPA C18:0 | Metabolite | lipidmaps:LMGP10050005 | |
| LPA C18:1 | Metabolite | lipidmaps:LMGP10050008 | |
| LPA C20:4 | Metabolite | lipidmaps:LMGP10050013 | |
| LPA C20:3 | Metabolite | lipidmaps:LMGP10050028 | |
| LPA C18:2 | Metabolite | lipidmaps:LMGP10050017 | |
| LPA C20:5 | Metabolite | lipidmaps:LMGP10050033 | |
| LPA C22:4 | Metabolite | lipidmaps:LMGP10050020 | |
| LPA C22:5 | Metabolite | hmdb:HMDB0114753 | |
| LPA C22:6 | Metabolite | lipidmaps:LMGP10050019 | |
| PC C14:0 | Metabolite | lipidmaps:LMGP01050012 | |
| PC C16:0 | Metabolite | lipidmaps:LMGP01050018 | |
| PC C16:1 | Metabolite | lipidmaps:LMGP01050021 | |
| PC C18:0 | Metabolite | lipidmaps:LMGP01050026 | |
| PC C18:1 | Metabolite | lipidmaps:LMGP01050032 | |
| PC C18:2 | Metabolite | lipidmaps:LMGP01050034；LMGP01050035 | |
| PE | Metabolite | lipidmaps:LMGP02010000 | |
| LPE C14:0 | Metabolite | lipidmaps:LMGP02050003 | |
| LPE C16:0 | Metabolite | lipidmaps:LMGP02050002 | |
| LPE C16:1 | Metabolite | lipidmaps:LMGP02050010 | |
| LPE C18:0 | Metabolite | lipidmaps:LMGP02050001 | |
| LPE C18:1 | Metabolite | lipidmaps:LMGP02050039 | |
| LPE C18:2 | Metabolite | lipidmaps:LMGP02050011 | |
| LPE C18:3 | Metabolite | lipidmaps:LMGP02050042 | |
| LPE C20:3 | Metabolite | lipidmaps:LMGP02050042 | |
| LPE C20:4 | Metabolite | lipidmaps:LMGP02050009 | |
| LPE C20:5 | Metabolite | lipidmaps:LMGP02050027 | |
| LPE C22:4 | Metabolite | lipidmaps:LMGP02050014 | |
| LPE C22:5 | Metabolite | lipidmaps:LMGP02050058 | |
| LPE C22:6 | Metabolite | lipidmaps:LMGP02050013 | |
| cLPA C14:0 | Metabolite | lipidmaps:LMGP00000070 | |
| cLPA C16:0 | Metabolite | lipidmaps:LMGP00000057 | |
| cLPA C16:1 | Metabolite | cas:910228-13-6 | |
| cLPA C18:0 | Metabolite | lipidmaps:LMGP00000055 | |
| cLPA C18:1 | Metabolite | lipidmaps:LMGP00000056 | |
| cLPA C18:2 | Metabolite | hmdb:HMDB0007007 | |
| PG | Metabolite | lipidmaps:LMGP04010000 | |
| LPG C14:0 | Metabolite | lipidmaps:LMGP04050012 | |
| LPG C16:0 | Metabolite | lipidmaps:LMGP04050008 | |
| LPG C16:1 | Metabolite | lipidmaps:LMGP04050013 | |
| LPG C18:0 | Metabolite | lipidmaps:LMGP04050009 | |
| LPG C18:1 | Metabolite | lipidmaps:LMGP04050006 | |
| LPG C18:2 | Metabolite | lipidmaps:LMGP04050014 | |
| LPG C18:3 | Metabolite | lipidmaps:LMGP04050032 | |
| LPG C20:3 | Metabolite | lipidmaps:LMGP04050025 | |
| LPG C20:4 | Metabolite | lipidmaps:LMGP04050010 | |
| LPG C20:5 | Metabolite | lipidmaps:LMGP04050030 | |
| LPG C22:4 | Metabolite | lipidmaps:LMGP04050017 | |
| LPG C22:6 | Metabolite | lipidmaps:LMGP04050016 | |
| PI | Metabolite | lipidmaps:LMGP06010000 | |
| PS | Metabolite | lipidmaps:LMGP03010000 | |
| LPS C16:0 | Metabolite | lipidmaps:LMGP03050002 | |
| LPS C18:0 | Metabolite | lipidmaps:LMGP03050006 | |
| LPS C18:1 | Metabolite | lipidmaps:LMGP03050001 | |
| LPS C18:2 | Metabolite | lipidmaps:LMGP03050011 | |
| LPS C20:4 | Metabolite | lipidmaps:LMGP03050007 | |
| LPS C22:4 | Metabolite | lipidmaps:LMGP03050014 | |
| LPS C22:6 | Metabolite | lipidmaps:LMGP03050013 | |
| LPI C14:0 | Metabolite | lipidmaps:LMGP06050008 | |
| LPI C16:0 | Metabolite | lipidmaps:LMGP06050002 | |
| LPI C16:1 | Metabolite | lipidmaps:LMGP06050009 | |
| LPI C18:0 | Metabolite | lipidmaps:LMGP06050004 | |
| LPI C18:1 | Metabolite | lipidmaps:LMGP06050005 | |
| LPI C18:2 | Metabolite | lipidmaps:LMGP06050010 | |
| LPI C20:4 | Metabolite | lipidmaps:LMGP06050006 | |
| LPI C22:4 | Metabolite | lipidmaps:LMGP06050013 | |
| LPI C22:6 | Metabolite | lipidmaps:LMGP06050012 | |
| AA | Metabolite | lipidmaps:LMFA01030001 | |
| 5,6-DiHETrE | Metabolite | lipidmaps:LMFA03050004 | |
| 20-HETE | Metabolite | lipidmaps:LMFA03060009 | |
| 15-HpETE | Metabolite | lipidmaps:LMFA03060014 | |
| 15-HETE | Metabolite | lipidmaps:LMFA03060087 | |
| 15-KETE | Metabolite | lipidmaps:LMFA03060051 | |
| 12-HpETE | Metabolite | lipidmaps:LMFA03060013 | |
| 12-HETE | Metabolite | lipidmaps:LMFA03060088 | |
| 12-KETE | Metabolite | lipidmaps:LMFA03060019 | |
| 5-HETE | Metabolite | lipidmaps:LMFA03060084 | |
| 5-KETE | Metabolite | lipidmaps:LMFA03060011 | |
| 5,15-DiHETE | Metabolite | lipidmaps:LMFA03060107 | |
| 8,15-DiHETE | Metabolite | lipidmaps:LMFA03060050 | |
| 5-HpETE | Metabolite | lipidmaps:LMFA03060012 | |
| 8,9-EpETrE | Metabolite | lipidmaps:LMFA03080003 | |
| 11,12-EpETrE | Metabolite | lipidmaps:LMFA03080004 | |
| 14,15-EpETrE | Metabolite | lipidmaps:LMFA03080005 | |
| 8,9-DiHETrE | Metabolite | lipidmaps:LMFA03050006 | |
| 11,12-DiHETrE | Metabolite | lipidmaps:LMFA03050008 | |
| 14,15-DiHETrE | Metabolite | lipidmaps:LMFA03050010 | |
| 8-HpETE | Metabolite | lipidmaps:LMFA03060073 | |
| 9-HpETE | Metabolite | lipidmaps:LMFA03060072 | |
| 11-HpETE | Metabolite | lipidmaps:LMFA03060071 | |
| 8-HETE | Metabolite | lipidmaps:LMFA03060086 | |
| 9-HETE | Metabolite | lipidmaps:LMFA03060089 | |
| 11-HETE | Metabolite | lipidmaps:LMFA03060085 | |
| PGG2 | Metabolite | lipidmaps:LMFA03010009 | |
| PGH2 | Metabolite | lipidmaps:LMFA03010010 | |
| PGA2 | Metabolite | lipidmaps:LMFA03010035 | |
| PGE2 | Metabolite | lipidmaps:LMFA03010003 | |
| PGC2 | Metabolite | lipidmaps:LMFA03010133 | |
| PGB2 | Metabolite | lipidmaps:LMFA03010018 | |
| 20-hydroxy-PGF2α | Metabolite | lipidmaps:LMFA03010029 | |
| 2,3dinor-11β-PGF2α | Metabolite | lipidmaps:LMFA03010011 | |
| 11β-PGF2α | Metabolite | lipidmaps:LMFA03010036 | |
| 13,14-dihydro-15keto-PGF2α | Metabolite | lipidmaps:LMFA03010027 | |
| 13,14-dihydro-PGF2α | Metabolite | lipidmaps:LMFA03010079 | |
| 1a,1b-dihomo-PGF2α | Metabolite | lipidmaps:LMFA03010157 | |
| 15keto-PGF2α | Metabolite | lipidmaps:LMFA03010026 | |
| PGD2 | Metabolite | lipidmaps:LMFA03010004 | |
| PGK2 | Metabolite | lipidmaps:LMFA03010019 | |
| 20-hydroxy-PGE2 | Metabolite | lipidmaps:LMFA03010014 | |
| 11β-PGE2 | Metabolite | lipidmaps:LMFA03010060 | |
| 13,14-dihydro-15keto-PGE2 | Metabolite | lipidmaps:LMFA03010031 | |
| bicyclo-PGE2 | Metabolite | lipidmaps:LMFA03010034 | |
| thromboxane-A2 | Metabolite | lipidmaps:LMFA03030001 | |
| thromboxane-B2 | Metabolite | lipidmaps:LMFA03030002 | |
| 13,14-dihydro-15keto-PGD2 | Metabolite | lipidmaps:LMFA03010022 | |
| 15deoxy-12,14-PGD2 | Metabolite | lipidmaps:LMFA03010051 | |
| PGJ2 | Metabolite | lipidmaps:LMFA03010019 | |
| 2,3dinor-8-iso-PGF2α | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-15R-PGF2α | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-PGF2α | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-PGE2 | Metabolite | lipidmaps:LMFA03010014 | |
| 5-iPF2α-VI | Metabolite | lipidmaps:LMFA03010014 | |
| 8,12-iso-iPF2α-VI | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-13,14-dihydro-15keto-PGF2α | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-PGA2 | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-15keto-PGE2 | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-15keto-PGF2β | Metabolite | lipidmaps:LMFA03010014 | |
| 8-iso-15keto-PGF2α | Metabolite | lipidmaps:LMFA03010014 | |
| 12-HHTrE | Metabolite | lipidmaps:LMFA03050002 | |
| LipoxinA4 | Metabolite | lipidmaps:LMFA03040001 | |
| LipoxinB4 | Metabolite | lipidmaps:LMFA03040002 | |
| 20-hydroxy-LTB4 | Metabolite | lipidmaps:LMFA03020018 | |
| 20-carboxy-LTB4 | Metabolite | lipidmaps:LMFA03020016 | |
| 14,15-LTE4 | Metabolite | lipidmaps:LMFA03020033 | |
| LTC4 | Metabolite | lipidmaps:LMFA03020003 | |
| LTB4 | Metabolite | lipidmaps:LMFA03020001 | |
| 6trans-LTB4 | Metabolite | lipidmaps:LMFA03020013 | |
| LTE4 | Metabolite | lipidmaps:LMFA03020002 | |
| 11trans-LTE4 | Metabolite | lipidmaps:LMFA03020022 | |
| LTA4 | Metabolite | lipidmaps:LMFA03020023 | |
| DHA | Metabolite | lipidmaps:LMFA01030185 | |
| 13-HDoHE | Metabolite | lipidmaps:LMFA04000029 | |
| 16,17-EpDPE | Metabolite | lipidmaps:LMFA04000037 | |
| 19,20-EpDPE | Metabolite | lipidmaps:LMFA04000038 | |
| 19,20-DiHDPA | Metabolite | lipidmaps:LMFA04000043 | |
| 16,17-DiHDPA | Metabolite | lipidmaps:LMFA04000042 | |
| 20-HDoHE | Metabolite | lipidmaps:LMFA04000033 | |
| 8-HDoHE | Metabolite | lipidmaps:LMFA04000026 | |
| 11-HDoHE | Metabolite | lipidmaps:LMFA04000028 | |
| 14-HDoHE | Metabolite | lipidmaps:LMFA04000030 | |
| 11-HpDoHE | Metabolite | chebi:156131 | |
| 14-HpDoHE | Metabolite | chebi:140279 | |
| 7-HpDoHE | Metabolite | chebi:156049 | |
| 4-HDoHE | Metabolite | lipidmaps:LMFA04000024 | |
| 7-HDoHE | Metabolite | lipidmaps:LMFA04000025 | |
| 10-HpDoHE | Metabolite | chebi:136657 | |
| 17-HpDoHE | Metabolite | lipidmaps:LMFA04000051 | |
| 10-HDoHE | Metabolite | lipidmaps:LMFA04000027 | |
| 16-HDoHE | Metabolite | lipidmaps:LMFA04000031 | |
| 17-HDoHE | Metabolite | lipidmaps:LMFA04000032 | |
| ResolvinD1 | Metabolite | lipidmaps:LMFA04030011 | |
| ResolvinD2 | Metabolite | lipidmaps:LMFA04030001 | |
| Maresin1 | Metabolite | lipidmaps:LMFA04050001 | |
| 10,17-DiHDoHE | Metabolite | lipidmaps:LMFA04040003 | |
| 15-HpEPE | Metabolite | lipidmaps:LMFA03070013 | |
| 5-HEPE | Metabolite | lipidmaps:LMFA03070027 | |
| 12-HEPE | Metabolite | lipidmaps:LMFA03070031 | |
| 5-HpEPE | Metabolite | lipidmaps:LMFA03070001 | |
| 12-HpEPE | Metabolite | lipidmaps:LMFA03070012 | |
| 15-HEPE | Metabolite | lipidmaps:LMFA03070032 | |
| 18-HEPE | Metabolite | lipidmaps:LMFA03070033 | |
| Resolvin E1 | Metabolite | lipidmaps:LMFA03140003 | |
| Resolvin E2 | Metabolite | lipidmaps:LMFA03140011 | |
| 14,15-EpETE | Metabolite | lipidmaps:LMFA03000003 | |
| 17,18-EpETE | Metabolite | lipidmaps:LMFA03000004 | |
| 14,15-DiHETE | Metabolite | lipidmaps:LMFA03060077 | |
| 17,18-DiHETE | Metabolite | lipidmaps:LMFA03060078 | |
| EPA | Metabolite | lipidmaps:LMFA01030759 | |
| 9-HEPE | Metabolite | lipidmaps:LMFA03070029 | |
| 9-HpEPE | Metabolite | lipidmaps:LMFA03070057 | |
| LipoxinA5 | Metabolite | lipidmaps:LMFA03040012 | |
| PGA3 | Metabolite | lipidmaps:LMFA03010140 | |
| PGE3 | Metabolite | lipidmaps:LMFA03010135 | |
| PGH3 | Metabolite | chebi:134407 | |
| PGG3 | Metabolite | chebi:134406 | |
| PGF2α | Metabolite | lipidmaps:LMFA03010002 | |
| PGF3α | Metabolite | lipidmaps:LMFA03010138 | |
| 8-iso-PGF3α | Metabolite | lipidmaps:LMFA03110007 | |
| PGD3 | Metabolite | lipidmaps:LMFA03010142 | |
| thromboxane-A3 | Metabolite | lipidmaps:LMFA03030005 | |
| thromboxane-B3 | Metabolite | lipidmaps:LMFA03030006 | |
| LA | Metabolite | lipidmaps:LMFA01030120 | |
| 9,10-EpOME | Metabolite | lipidmaps:LMFA02000037 | |
| 12,13-EpOME | Metabolite | lipidmaps:LMFA02000038 | |
| 9,10-DiHOME | Metabolite | lipidmaps:LMFA02000229 | |
| 12,13-DiHOME | Metabolite | lipidmaps:LMFA02000230 | |
| 9,10,13-TriHOME | Metabolite | lipidmaps:LMFA02000168 | |
| 9,12,13-TriHOME | Metabolite | lipidmaps:LMFA02000014 | |
| 9-HpODE | Metabolite | lipidmaps:LMFA02000012 | |
| 13-HpODE | Metabolite | lipidmaps:LMFA02000034 | |
| 9-HODE | Metabolite | lipidmaps:LMFA02000151 | |
| 13-HODE | Metabolite | lipidmaps:LMFA02000154 | |
| 9-KODE | Metabolite | lipidmaps:LMFA02000274 | |
| 13-KODE | Metabolite | lipidmaps:LMFA02000016 | |
| DGLA | Metabolite | lipidmaps:LMFA01030158 | |
| GLA | Metabolite | lipidmaps:LMFA01030141 | |
| 13,14-dihydro-15keto-PGD1 | Metabolite | lipidmaps:LMFA03010255 | |
| 13,14-dihydro-15keto-PGF1α | Metabolite | lipidmaps:LMFA03010168 | |
| 6-keto-PGF1α | Metabolite | lipidmaps:LMFA03010001 | |
| 15-keto-PGF1α | Metabolite | lipidmaps:LMFA03010150 | |
| PGF1α | Metabolite | lipidmaps:LMFA03010137 | |
| thromboxane-B1 | Metabolite | lipidmaps:LMFA03030008 | |
| PGD1 | Metabolite | lipidmaps:LMFA03010049 | |
| PGG1 | Metabolite | chebi:133793 | |
| PGH1 | Metabolite | chebi:91133 | |
| PGE1 | Metabolite | lipidmaps:LMFA03010134 | |
| PGA1 | Metabolite | lipidmaps:LMFA03010005 | |
| 6-keto-PGE1 | Metabolite | lipidmaps:LMFA03010012 | |
| 8-HETrE | Metabolite | lipidmaps:LMFA03050011 | |
| 15-HETrE | Metabolite | lipidmaps:LMFA03050007 | |
| 8-iso-PGA1 | Metabolite | lipidmaps:LMFA03110008 | |
| 8-iso-PGE1 | Metabolite | lipidmaps:LMFA03110002 | |
| NO2-LA | Metabolite | lipidmaps:LMFA01120001 | |
| Cholesterol | Metabolite | lipidmaps:LMST04010032 | |
| GUDCA | Metabolite | lipidmaps:LMST05030016 | |
| GDCA | Metabolite | lipidmaps:LMST05030006 | |
| GLCA | Metabolite | lipidmaps:LMST05030009 | |
| TUDCA | Metabolite | lipidmaps:LMST05040015 | |
| THDCA | Metabolite | chebi:139138 | |
| TDCA | Metabolite | lipidmaps:LMST05040013 | |
| TLCA | Metabolite | lipidmaps:LMST05040003 | |
| DCA | Metabolite | lipidmaps:LMST04010040 | |
| LCA | Metabolite | lipidmaps:LMST04010003 | |
| UDCA | Metabolite | lipidmaps:LMST04010033 | |
| HDCA | Metabolite | lipidmaps:LMST04010024 | |
| HCA | Metabolite | lipidmaps:LMST04010064 | |
| GCA | Metabolite | lipidmaps:LMST05030001 | |
| CA | Metabolite | lipidmaps:LMST04010001 | |
| GCDCA | Metabolite | lipidmaps:LMST05030008 | |
| CDCA | Metabolite | lipidmaps:LMST04010032 | |
| TCDCA | Metabolite | lipidmaps:LMST05040005 | |
| TCA | Metabolite | lipidmaps:LMST05040001 | |
| 7α-hydroxycholesterol | Metabolite | lipidmaps:LMST01010013 | |
| 27α-hydroxycholesterol | Metabolite | lipidmaps:LMST01010057 | |
| 2-AG/1-AG | Metabolite | lipidmaps:LMGL01010032 | |
| 2-OG/1-OG | Metabolite | lipidmaps:LMGL01010005 | |
| 2-LG/1-LG | Metabolite | lipidmaps:LMGL01010006 | |
| LEA | Metabolite | lipidmaps:LMFA08040007 | |
| POEA | Metabolite | lipidmaps:LMFA08040043 | |
| PDEA | Metabolite | lipidmaps:LMFA08040045 | |
| AEA | Metabolite | lipidmaps:LMFA08040001 | |
| DHEA | Metabolite | lipidmaps:LMFA08040009 | |
| PEA | Metabolite | lipidmaps:LMFA08040013 | |
| DGLEA | Metabolite | lipidmaps:LMFA08040011 | |
| DEA | Metabolite | lipidmaps:LMFA08040047 | |
| SEA | Metabolite | lipidmaps:LMFA08040051 | |
| NADA | Metabolite | lipidmaps:LMFA08020084 | |
| OEA | Metabolite | lipidmaps:LMFA08040015 | |
| EPEA | Metabolite | lipidmaps:LMFA08040008 | |
| ETAEA | Metabolite | lipidmaps:LMFA08040037 | |
| PC | Metabolite | lipidmaps:LMGP01010000 | |
| DAGs | Metabolite | lipidmaps:LMGL0201 | |
| NAPEs | Metabolite | pubchem.compound:99647627 | |
| CYP epoxygenase | GeneProduct | uniprot:P11712 | |
| CYP2 | Protein | uniprot:P20813 | |
| PLA1 | Protein | uniprot:Q53H76 | |
| PLA2 | Protein | uniprot:P04054 | |
| ALOX5 | Protein | uniprot:P09917 | |
| GPX4 | Protein | uniprot:P36969 | |
| ALOX15 | Protein | uniprot:P16050 | |
| ALOX12 | Protein | uniprot:P18054 | |
| EPHX2 | Protein | uniprot:P34913 | |
| CYP4 | Protein | uniprot:P78329 | |
| COX1 | Protein | uniprot:P00395 | |
| COX2 | Protein | uniprot:P35354 | |
| PTGES | Protein | uniprot:O14684 | |
| CBR1 | Protein | uniprot:P16152 | |
| HPGD | Protein | uniprot:P15428 | |
| PTGDS | Protein | uniprot:P41222 | |
| TBXAS1 | Protein | uniprot:P24557 | |
| LTA4H | Protein | uniprot:P09960 | |
| LTC4S | Protein | uniprot:Q16873 | |
| CYP2 | Protein | uniprot:P10632 | |
| PRXL2B | Protein | uniprot:Q8TBF2 | |
| FADS2 | Protein | uniprot:O95864 | |
| CYP7A1 | Protein | uniprot:P22680 | |
| CYP27A1 | Protein | uniprot:Q02318 | |
| CYP7B1 | Protein | uniprot:O75881 | |
| CYP8B1 | Protein | uniprot:Q9UNU6 | |
| PLC | Protein | uniprot:Q9NQ66 |
References
- A comprehensive UHPLC-MS/MS method for metabolomics profiling of signaling lipids: Markers of oxidative stress, immunity and inflammation. Yang W, Schoeman JC, Di X, Lamont L, Harms AC, Hankemeier T. Anal Chim Acta. 2024 Apr 8;1297:342348. PubMed Europe PMC Scholia