PFAS in Dutch population (WP5579)

Homo sapiens

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A recent study by the Dutch RIVM found that across The Netherlands seven PFAS are found in every tested human, with an additional nine found in at least 10% of the population. Three of these PFAS were found to be associated to cancer. PFOS, PFHxS, and PFOA were found to be significantly positively associated with testicular germ cell tumors (TGCT) among U.S. Air Force servicemen [PMID:37458713 ]. Data from a 2-year bioassay study on rats did not support a PFOS-related effect on testicular tumors, while serum PFOS concentrations were much higher in magnitude compared to levels reported in the former study [PMID:37751326]. This last study focussed on Leydig cell tumors (LCTs), which were described to not be comparable to TGCT [PMID:38099920]. Furthermore, the animal model used in that study (Sprague-Dawley rats) for assessing environmental risk factors of human LCTs is questionable due to mechanistic differences in carcinogenesis as well as incidence rate of spontaneous LCTs [PMID:38099920]. This literary discussion concluded with another article, suggesting that the data collected on rats was not directly translational to humans, but should be included to obtain a full view of the potential effects of PFAS compounds [PMID:38099921].

For a description of pathway objects, see the WikiPathways Legend.

Authors

Egon Willighagen and Denise Slenter

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway

Disease Ontology

testicular cancer testicular germ cell cancer

Participants

Label Type Compact URI Comment
PFPeA Metabolite wikidata:Q27156873
PFHpA Metabolite wikidata:Q27116513
PFOA Metabolite wikidata:Q418348 perfluorooctanoic acid
PFNA Metabolite wikidata:Q7168161
PFDA Metabolite wikidata:Q27116511
PFUnDA Metabolite wikidata:Q27156875
PFHxS Metabolite wikidata:Q26833878 perfluorohexanesulfonic acid
PFHpS Metabolite wikidata:Q72500529
PFOS Metabolite wikidata:Q902094 perfluorooctanesulfonic acid
PFDoDA Metabolite wikidata:Q27162640
PFBS Metabolite wikidata:Q410426
PFPeS Metabolite wikidata:Q81976952
8:2 FTS Metabolite wikidata:Q66828157
MeFOSAA Metabolite wikidata:Q27156889
EtFOSAA Metabolite wikidata:Q27156890
9Cl-PF3ONS Metabolite wikidata:Q81982190

References

  1. A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen. Purdue MP, Rhee J, Denic-Roberts H, McGlynn KA, Byrne C, Sampson J, et al. Environ Health Perspect. 2023 Jul;131(7):77007. PubMed Europe PMC Scholia
  2. Comment on “A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen.” Olsen GW, Chang S, Taiwo OA. Environ Health Perspect. 2023 Sep;131(9):98001. PubMed Europe PMC Scholia
  3. Comment on “Comment on ‘A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen.’” Shioda T, Weiss RS, Bagrodia A, Frazier AL. Environ Health Perspect. 2023 Dec;131(12):128001. PubMed Europe PMC Scholia
  4. Response to “Comment on ‘Comment on “A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen.”’” Olsen GW, Chang S, Taiwo OA. Environ Health Perspect. 2023 Dec;131(12):128002. PubMed Europe PMC Scholia