Glycerol metabolism including linked IMDs (WP5570)

Homo sapiens

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This Pathway is a schematic representation of Glycerol metabolism, which is an important intermediate metabolite, acting as a bridge between carbohydrate and lipid metabolism. This pathway also depicts inherited metabolic diseases that disrupt glycerol metabolism including: Glycerol kinase deficiency, Glycerate kinase deficiency, Aquaporin 7 deficiency and Cytosolic glycerol-3-phosphate dehydrogenase deficiency. This pathway was inspired by chapter 49 (Disorders of Glycerol Metabolism) of the book of Blau (ISBN 978-3-030-67726-8).

For a description of pathway objects, see the WikiPathways Legend.

Authors

Sander Lemmens , Egon Willighagen , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

glycerol kinase deficiency D-glyceric aciduria

Pathway Ontology

glycerol kinase deficiency pathway classic metabolic pathway disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
D-glyceraldehyde Metabolite chebi:17378
L-serine Metabolite chebi:33384
DHAP Metabolite chebi:57642
(R)-glycerate Metabolite chebi:16659
Triacylglycerol Metabolite chebi:88875
(2R)-3-phosphoglycerate Metabolite chebi:58272
Diacylglycerol Metabolite chebi:88376
Glycerol Metabolite chebi:17754
Glucose Metabolite chebi:17925
Monoacylglycerol Metabolite chebi:35759
fructose 1-phosphate Metabolite chebi:138881
Glycerol-3-P Metabolite chebi:57597 Is sn-glycerol 3-phosphate
(2R)-3-phospho-glyceroyl phosphate Metabolite chebi:57604
(2R)-2-phosphoglycerate Metabolite chebi:58289
phosphoenolpyruvate Metabolite chebi:58702
pyruvate Metabolite chebi:15361
oxaloacetate Metabolite chebi:16452
α-D-glucose 6-phosphate Metabolite chebi:58225
β-D-fructose 6-phosphate Metabolite chebi:57634
β-D-fructose 1,6-bisphosphate Metabolite chebi:32966
Glyceraldehyde-3-P Metabolite chebi:59776 Is D-glyceraldehyde 3-phosphate
FFAs Metabolite chebi:28868
DHAP Metabolite chebi:16108
fructose Metabolite chebi:28757
3-hydroxypyruvate Metabolite chebi:17180
GK Protein uniprot:P32189
AQP9 Protein uniprot:O43315
AQP7 Protein uniprot:O14520
GPD1 Protein uniprot:P21695
ATGL Protein uniprot:Q96AD5
MGLL Protein uniprot:Q99685
HSL Protein uniprot:Q05469
GLYCTK Protein uniprot:Q8IVS8
GPD2 Protein uniprot:P43304
GAPDH Protein uniprot:P04406
Phosphoglycerate mutase 1 Protein uniprot:P18669
Phosphoglycerate kinase 1 Protein uniprot:P00558
Enolase Protein uniprot:P06733
Pyruvate kinase Protein uniprot:P30613
Pyruvate carboxylase Protein uniprot:P11498
Phosphoenolpyruvate carboxykinase Protein uniprot:P35558
Phosphofructokinase 1 Protein uniprot:P17858
Fructose-1,6-bisphosphatase 1 Protein uniprot:P09467
Glucose-6-phosphate isomerase Protein uniprot:P06744
Hexokinase-1 Protein uniprot:P19367
Glucose-6-phosphatase Protein uniprot:P35575
Triosephosphate isomerase Protein uniprot:P60174
Aldolase Protein uniprot:P04075
Aldo-keto reductase family 1 Protein uniprot:P14550
Ketohexokinase Protein uniprot:P50053
Fructose-bisphosphate aldolase B Protein uniprot:P05062
L-serine dehydratase Protein uniprot:P20132
aminotransferase Protein uniprot:P21549
hydroxypyruvate reductase Protein uniprot:Q9UBQ7

References

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