RNA Polymerase II transcription: the preinitiation complex (WP5563)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

RNA Polymerase II transcription: the preinitiation complex

For a description of pathway objects, see the WikiPathways Legend.

Authors

Jmlohmann

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Participants
Query Drugst.One

Label Type Compact URI Comment
TAF3 GeneProduct ensembl:ENSG00000165632
TAF9 GeneProduct ensembl:ENSG00000273841
MED24 GeneProduct ensembl:ENSG00000008838
NELFCD GeneProduct ensembl:ENSG00000101158
ELK1 GeneProduct ensembl:ENSG00000126767
MED13 GeneProduct ensembl:ENSG00000108510
NELFB GeneProduct ensembl:ENSG00000188986
THRA GeneProduct ensembl:ENSG00000126351
POLR2M GeneProduct ensembl:ENSG00000255529
CDK8 GeneProduct ensembl:ENSG00000132964
CCNC GeneProduct ensembl:ENSG00000112237
NELFE GeneProduct ensembl:ENSG00000204356
MED12 GeneProduct ensembl:ENSG00000184634
NELFA GeneProduct ensembl:ENSG00000185049
MED14 GeneProduct ensembl:ENSG00000180182
MED28 GeneProduct ensembl:ENSG00000118579
MED6 GeneProduct ensembl:ENSG00000133997
MED31 GeneProduct ensembl:ENSG00000108590
MED23 GeneProduct ensembl:ENSG00000112282
MED4 GeneProduct ensembl:ENSG00000136146
TAF8 GeneProduct ensembl:ENSG00000137413
MED11 GeneProduct ensembl:ENSG00000161920
MED15 GeneProduct ensembl:ENSG00000099917
TAF7 GeneProduct ensembl:ENSG00000178913
MED19 GeneProduct ensembl:ENSG00000156603
MED21 GeneProduct ensembl:ENSG00000152944
TAF4 GeneProduct ensembl:ENSG00000130699
H4C5 GeneProduct ensembl:ENSG00000276966
CTDP1 GeneProduct ensembl:ENSG00000060069
MED25 GeneProduct ensembl:ENSG00000104973
TAF11 GeneProduct ensembl:ENSG00000064995
H4C3 GeneProduct hgnc.symbol:H4C3
TAF2 GeneProduct ensembl:ENSG00000064313
TAF5 GeneProduct ensembl:ENSG00000148835
MED9 GeneProduct ensembl:ENSG00000141026
MED20 GeneProduct ensembl:ENSG00000124641
MED8 GeneProduct ensembl:ENSG00000159479
MED17 GeneProduct ensembl:ENSG00000042429
MED1 GeneProduct ensembl:ENSG00000125686
MED10 GeneProduct ensembl:ENSG00000133398
TAF10 GeneProduct ensembl:ENSG00000166337
MED26 GeneProduct ensembl:ENSG00000105085
TAF12 GeneProduct ensembl:ENSG00000120656
MED16 GeneProduct ensembl:ENSG00000175221
TAF6 GeneProduct ensembl:ENSG00000106290
MED22 GeneProduct ensembl:ENSG00000148297
ERCC3 GeneProduct ensembl:ENSG00000163161
MED30 GeneProduct ensembl:ENSG00000164758
MED29 GeneProduct ensembl:ENSG00000063322
TAF13 GeneProduct ensembl:ENSG00000197780
MED7 GeneProduct ensembl:ENSG00000155868
MED27 GeneProduct ensembl:ENSG00000160563
TAF1 GeneProduct ensembl:ENSG00000147133
MED18 GeneProduct ensembl:ENSG00000130772
TBP GeneProduct ensembl:ENSG00000112592
GTF2F1 GeneProduct ensembl:ENSG00000125651
GTF2E2 GeneProduct ensembl:ENSG00000197265
GTF2B GeneProduct ensembl:ENSG00000137947
GTF2A1 GeneProduct ensembl:ENSG00000165417

References

  1. Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Tirode F, Busso D, Coin F, Egly JM. Mol Cell. 1999 Jan;3(1):87–95. PubMed Europe PMC Scholia
  2. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, et al. Cell. 1999 Apr 2;97(1):41–51. PubMed Europe PMC Scholia
  3. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, et al. Mol Cell Biol. 2003 Mar;23(6):1863–73. PubMed Europe PMC Scholia
  4. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. Visconti R, Palazzo L, Della Monica R, Grieco D. Nat Commun. 2012 Jun 12;3:894. PubMed Europe PMC Scholia
  5. Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Goodfellow SJ, Zomerdijk JCBM. Subcell Biochem. 2013;61:211–36. PubMed Europe PMC Scholia
  6. The Mediator complex: a central integrator of transcription. Allen BL, Taatjes DJ. Nat Rev Mol Cell Biol. 2015 Mar;16(3):155–66. PubMed Europe PMC Scholia
  7. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E. Nature. 2016 Mar 31;531(7596):604–9. PubMed Europe PMC Scholia
  8. Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. Sandoz J, Nagy Z, Catez P, Caliskan G, Geny S, Renaud JB, et al. Nat Commun. 2019 Mar 20;10(1):1288. PubMed Europe PMC Scholia
  9. MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia. Meng L, Isohanni P, Shao Y, Graham BH, Hickey SE, Brooks S, et al. Ann Neurol. 2021 Apr;89(4):828–33. PubMed Europe PMC Scholia
  10. The Mediator complex as a master regulator of transcription by RNA polymerase II. Richter WF, Nayak S, Iwasa J, Taatjes DJ. Nat Rev Mol Cell Biol. 2022 Nov;23(11):732–49. PubMed Europe PMC Scholia
  11. Structures of +1 nucleosome-bound PIC-Mediator complex. Chen X, Wang X, Liu W, Ren Y, Qu X, Li J, et al. Science. 2022 Oct 7;378(6615):62–8. PubMed Europe PMC Scholia