HINT1 pathway (WP5523)

Homo sapiens

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HINT1 is a protein that can be mutated in charcot marie tooth disease.

Authors

Julen van Ham , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

Charcot-Marie-Tooth disease

Pathway Ontology

disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Guanosine 5'-monophosphorothioate Metabolite pubchem.compound:135405922
5'-AMP Metabolite chebi:16027
3'-lysyl-AMP Metabolite chebi:131569
ATP Metabolite chebi:30616
lysine Metabolite chebi:25094
cyclin H GeneProduct uniprot:P51946
TCF4 GeneProduct uniprot:P15884
NFκB1 GeneProduct uniprot:P19838
CTNNB1 GeneProduct uniprot:P35222
CDK7 GeneProduct ensembl:ENSG00000134058
NFATC2 GeneProduct uniprot:Q13469
FOS GeneProduct uniprot:P01100
KARS1 GeneProduct ensembl:ENSG00000065427
USF2 GeneProduct ensembl:ENSG00000105698
MITF GeneProduct ensembl:ENSG00000187098
HINT1 GeneProduct ensembl:ENSG00000169567
JUN GeneProduct ensembl:ENSG00000177606
SH3RF1 GeneProduct ensembl:ENSG00000154447
MAPK9 GeneProduct ensembl:ENSG00000050748
RUVB2 GeneProduct uniprot:Q9Y230
RUVB1 GeneProduct uniprot:Q9Y265
MAT1 GeneProduct uniprot:P51948
TF2H5 GeneProduct uniprot:Q6ZYL4
TF2H3 GeneProduct uniprot:Q13889
TF2H2 GeneProduct uniprot:Q13888
TF2H4 GeneProduct uniprot:Q92759
TF2H1 GeneProduct uniprot:P32780
ERCC3 GeneProduct uniprot:P19447
ERCC2 GeneProduct uniprot:P18074

References

  1. The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. Weiske J, Huber O. J Cell Sci. 2005 Jul 15;118(Pt 14):3117–29. PubMed Europe PMC Scholia
  2. Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. Cancer Res. 2007 May 15;67(10):4700–8. PubMed Europe PMC Scholia
  3. HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. Wang L, Li H, Zhang Y, Santella RM, Weinstein IB. Int J Cancer. 2009 Apr 1;124(7):1526–34. PubMed Europe PMC Scholia
  4. Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5’-O-phosphorothioates to nucleoside 5’-O-phosphates. Ozga M, Dolot R, Janicka M, Kaczmarek R, Krakowiak A. J Biol Chem. 2010 Dec 24;285(52):40809–18. PubMed Europe PMC Scholia
  5. Hit proteins, mitochondria and cancer. Martin J, St-Pierre MV, Dufour JF. Biochim Biophys Acta. 2011 Jun;1807(6):626–32. PubMed Europe PMC Scholia
  6. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor. Wang J, Fang P, Schimmel P, Guo M. J Phys Chem B. 2012 Jun 14;116(23):6798–805. PubMed Europe PMC Scholia
  7. Axonal neuropathy with neuromyotonia: there is a HINT. Peeters K, Chamova T, Tournev I, Jordanova A. Brain. 2017 Apr 1;140(4):868–77. PubMed Europe PMC Scholia