Neural crest development (WP548)

Danio rerio

This pathway displays genes required for different processes in neural crest development. It is based on genetic and signaling interactions.


Georg W. Otto , Daniela Digles , and Kristina Hanspers


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Danio rerio



Pathway Ontology

signaling pathway pertinent to development


Label Type Compact URI Comment
snai1b GeneProduct ncbigene:30182
dlx4b GeneProduct ncbigene:30581
bcmo1 GeneProduct ncbigene:84039
dlx3b GeneProduct ncbigene:30585
pah GeneProduct ncbigene:378962
plp1b GeneProduct ncbigene:368234
csf1r GeneProduct ncbigene:64274
plp1a GeneProduct ncbigene:64264
ednrb1 GeneProduct ncbigene:30442
silvb GeneProduct ncbigene:562810
mbp GeneProduct ncbigene:326281
qdprb1 GeneProduct ncbigene:791448
zic2b GeneProduct ncbigene:570746
msxb GeneProduct ncbigene:30511
twist1a GeneProduct ncbigene:30175
twist1b GeneProduct ncbigene:550518
kitb GeneProduct ncbigene:497629
pts GeneProduct ncbigene:100073330
bmp7a GeneProduct ncbigene:30584
tyrp1b GeneProduct ncbigene:437022
msxe GeneProduct ncbigene:30527
zic5 GeneProduct ncbigene:403041
foxd3 GeneProduct ncbigene:30548
zic1 GeneProduct ncbigene:30096
aox3 GeneProduct ncbigene:64265
mbz GeneProduct ncbigene:114417
tyr GeneProduct ncbigene:30207
bmp2b GeneProduct ncbigene:30632
gchfr GeneProduct ncbigene:393735
wnt8a GeneProduct ncbigene:30122
dlx2a GeneProduct ncbigene:30574
myca GeneProduct ncbigene:30686
ltk GeneProduct ncbigene:564470
phox2b GeneProduct ncbigene:544654
tfap2a GeneProduct ncbigene:140618
pcbd1 GeneProduct ncbigene:393787
pax3a GeneProduct ncbigene:30532
sox10 GeneProduct ncbigene:140616
egr2b GeneProduct ncbigene:30190
sox9b GeneProduct ncbigene:60642
dlx1a GeneProduct ncbigene:30568
qdpra GeneProduct ncbigene:566323
slc45a2 GeneProduct ncbigene:558311
dlx3b GeneProduct ncbigene:30585
ret1 GeneProduct ncbigene:30512
mitfa GeneProduct ncbigene:30080
bmp7b GeneProduct ncbigene:557567
spra GeneProduct ncbigene:554136
dlx4a GeneProduct ncbigene:30561
zic2a GeneProduct ncbigene:58077
kita GeneProduct ncbigene:30256
dct GeneProduct ncbigene:58074
dlx5a GeneProduct ncbigene:30569
msxc GeneProduct ncbigene:30526
dlx4b GeneProduct ncbigene:30581
silva GeneProduct ncbigene:321239
oca2 GeneProduct ncbigene:567419
pax7a GeneProduct ncbigene:30587
slc24a5 GeneProduct ncbigene:570312
id2a GeneProduct ncbigene:266599
zic3 GeneProduct ncbigene:368263
gch2 GeneProduct ncbigene:64263


  1. Provitamin A conversion to retinal via the beta,beta-carotene-15,15’-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis. Lampert JM, Holzschuh J, Hessel S, Driever W, Vogt K, von Lintig J. Development. 2003 May;130(10):2173–86. PubMed Europe PMC Scholia
  2. Neural crest specification: migrating into genomics. Gammill LS, Bronner-Fraser M. Nat Rev Neurosci. 2003 Oct;4(10):795–805. PubMed Europe PMC Scholia
  3. Gene-regulatory interactions in neural crest evolution and development. Meulemans D, Bronner-Fraser M. Dev Cell. 2004 Sep;7(3):291–9. PubMed Europe PMC Scholia
  4. Central role of gene cooption in neural crest evolution. Meulemans D, Bronner-Fraser M. J Exp Zool B Mol Dev Evol. 2005 Jul 15;304(4):298–303. PubMed Europe PMC Scholia
  5. Leukocyte tyrosine kinase functions in pigment cell development. Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, et al. PLoS Genet. 2008 Mar 7;4(3):e1000026. PubMed Europe PMC Scholia
  6. The origin and evolution of the neural crest. Donoghue PCJ, Graham A, Kelsh RN. Bioessays. 2008 Jun;30(6):530–41. PubMed Europe PMC Scholia