Complement and coagulation cascades (WP547)

Rattus norvegicus

The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Source: [ KEGG]


Thomas Kelder , Kristina Hanspers , Alex Pico , Christine Chichester , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

coagulation cascade pathway complement system pathway


Label Type Compact URI Comment
Bradykinin Metabolite hmdb:HMDB0004246
F13b GeneProduct ncbigene:289055
Cfi GeneProduct ncbigene:79126
RGD:727845 GeneProduct ncbigene:302470
Masp2 GeneProduct ncbigene:64459
C7 GeneProduct ncbigene:117517
Serpina1 GeneProduct ncbigene:24648
F3 GeneProduct ncbigene:25584
Plat GeneProduct ncbigene:25692
Plau GeneProduct ncbigene:25619
Daf1 GeneProduct ncbigene:64036
Serpine1 GeneProduct ncbigene:24617
H2-Bf GeneProduct ncbigene:294257
Serpina5 GeneProduct ncbigene:65051
Pros1 GeneProduct ncbigene:81750
C1qb GeneProduct ncbigene:29687
Crry GeneProduct ncbigene:54243
Hc GeneProduct ncbigene:24441
Cr2 GeneProduct ncbigene:289395
C9 GeneProduct ncbigene:117512
Adn GeneProduct ncbigene:54249
C6 GeneProduct ncbigene:24237
F5 GeneProduct ensembl:ENSRNOG00000057855
Serpinc1 GeneProduct ncbigene:304917
Thbd GeneProduct ncbigene:83580
Crry GeneProduct ncbigene:54243
Kng1 GeneProduct ncbigene:24903
C2 GeneProduct ncbigene:24231
RGD:621759 GeneProduct ncbigene:116669
C1qg GeneProduct ncbigene:362634
C3 GeneProduct ncbigene:24232
RGD:735225 GeneProduct ncbigene:295703
Plaur GeneProduct ncbigene:50692
C1qa GeneProduct ncbigene:298566
Cfh GeneProduct ncbigene:155012
Serpinf2 GeneProduct ncbigene:287527
F11 GeneProduct ncbigene:290757
Tfpi GeneProduct ncbigene:29436
Masp1 GeneProduct ncbigene:64023
C3ar1 GeneProduct ncbigene:84007
Proc GeneProduct ncbigene:25268
C5r1 GeneProduct ncbigene:113959
C4a GeneProduct ncbigene:24233
F2r GeneProduct ncbigene:25439
Bdkrb1 GeneProduct ncbigene:81509
Mcp GeneProduct ncbigene:29333
A2m GeneProduct ncbigene:24153
C8b GeneProduct ncbigene:313421
Serpind1 GeneProduct ncbigene:79224
Cd59 GeneProduct ncbigene:25407
F2 GeneProduct ncbigene:29251
Cpb2 GeneProduct ncbigene:113936
Klkb1 GeneProduct ncbigene:25048
Fgb GeneProduct ncbigene:24366
Plg GeneProduct ncbigene:85253
C4bp GeneProduct ncbigene:24234
F9 GeneProduct ncbigene:24946
F12 GeneProduct ncbigene:306761
C1r GeneProduct ncbigene:312705
F10 GeneProduct ncbigene:29243
C1s GeneProduct ncbigene:192262
Mbl1 GeneProduct ncbigene:24548
F7 GeneProduct ncbigene:260320