Comprehensive IL-17A signaling (WP5242)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Schematic representation of IL-17A signaling pathway with a mix of human and mouse genes/proteins based on literature review.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Rex D A B , Egon Willighagen , Kristina Hanspers , Eric Weitz , and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

signaling pathway interleukin-17 family mediated signaling pathway

Participants

Label Type Compact URI Comment
Ccl3 GeneProduct ncbigene:20302
Cxcl5 GeneProduct ncbigene:20311
Fn1 GeneProduct ncbigene:14268
Ccl5 GeneProduct ncbigene:20304
VCAN GeneProduct ncbigene:1462
TGFB1 GeneProduct ncbigene:7040
Cdc42 GeneProduct ncbigene:12540
Acta1 GeneProduct ncbigene:11459
Crebbp GeneProduct uniprot:P45481
HSPG2 GeneProduct ncbigene:3339
ACTA2 GeneProduct ncbigene:59
Cxcl1 GeneProduct ncbigene:14825
Cxcl12 GeneProduct ncbigene:20315
COL5A2 GeneProduct ncbigene:1290
Ccl4 GeneProduct ncbigene:20303
MUC5AC GeneProduct ncbigene:4586
COL3A1 GeneProduct ncbigene:1281
CXCL2 GeneProduct ncbigene:2920
Acta2 GeneProduct ncbigene:11475
Igf1 GeneProduct ncbigene:16000
Baff GeneProduct ncbigene:24099
Fbn1 GeneProduct ncbigene:14118
IL1B GeneProduct uniprot:P01584.2
Hspa1b GeneProduct ncbigene:15511
Snai1 GeneProduct uniprot:Q02085
Mki67 GeneProduct ncbigene:17345
Mcm7 GeneProduct uniprot:Q61881
Adh1 GeneProduct ncbigene:11522
Hmgb1 GeneProduct ncbigene:15289
Col1a1 GeneProduct ncbigene:12842
Pdgfb GeneProduct ncbigene:18591
Hbb-bh1 GeneProduct ncbigene:15132
Sod2 GeneProduct ncbigene:20656
Plch1 GeneProduct ncbigene:269437
CXCL5 GeneProduct ncbigene:20311
P53 GeneProduct ncbigene:22059
IL17RA GeneProduct ncbigene:23765
Prkacb GeneProduct ncbigene:18749
MAPK1 GeneProduct ncbigene:5594 p38
MAPK3 GeneProduct ncbigene:5595
Anxa6 GeneProduct ncbigene:11749
Plau GeneProduct ncbigene:18792
Il1b GeneProduct ncbigene:16176
Ptgs2 GeneProduct ncbigene:19225
CXCL6 GeneProduct ncbigene:6372
Mmp3 GeneProduct ncbigene:17392
Stat1 GeneProduct ncbigene:20846
Akt1 GeneProduct ncbigene:207
IL17A GeneProduct ncbigene:3605
Ccn2 GeneProduct ncbigene:14219
Rac1 GeneProduct ncbigene:19353
MAPK14 GeneProduct ncbigene:1432 p38
Mtor GeneProduct ncbigene:56717
Mylk GeneProduct ncbigene:107589
Gng12 GeneProduct ncbigene:14701
Uggt1 GeneProduct ncbigene:320011
Il6 GeneProduct ncbigene:16193
Mcm5 GeneProduct ncbigene:17218
Casp3 GeneProduct ncbigene:12367
Pdgfa GeneProduct ncbigene:18590
Rab10 GeneProduct ncbigene:19325
Serpine1 GeneProduct ncbigene:66870
Cpne1 GeneProduct ncbigene:266692
NFKBIA GeneProduct ncbigene:4792
C3 GeneProduct ncbigene:12266
Arpc2 GeneProduct ncbigene:76709
CXCL1 GeneProduct ncbigene:2919
CFB GeneProduct ncbigene:629
Hbb-b2 GeneProduct ncbigene:15130
Col1a1 GeneProduct uniprot:P02452
Psmc6 GeneProduct ncbigene:67089
Plaur GeneProduct ncbigene:18793
Rela GeneProduct ncbigene:19697
CXCL3 GeneProduct ncbigene:2921
Ppp1r14b GeneProduct ncbigene:18938
Blmh GeneProduct ncbigene:104184
Snai2 GeneProduct uniprot:P97469
IL8 GeneProduct ncbigene:20309
Rhoa GeneProduct ncbigene:11848
Pak3 GeneProduct ncbigene:18481
GRK5 GeneProduct ncbigene:2869
Il1b GeneProduct uniprot:P10749
IL6 GeneProduct ncbigene:3569
C7 GeneProduct ncbigene:109828
Mmp14 GeneProduct ncbigene:17387
Arpc3 GeneProduct ncbigene:56378
Gap43 GeneProduct ncbigene:14432
PIK3CA GeneProduct ncbigene:5290
Rras2 GeneProduct ncbigene:66922
Arpc5 GeneProduct ncbigene:67771
Atox1 GeneProduct ncbigene:11927
Hyou1 GeneProduct ncbigene:12282
Pon3 GeneProduct ensembl:ENSMUSG00000029759
Angpt1 GeneProduct ensembl:ENSMUSG00000022309
IL-17A GeneProduct ncbigene:3605
Mmp9 GeneProduct ncbigene:17395
Cxcl2 GeneProduct ncbigene:20310
Hbb-b1 GeneProduct ncbigene:15129
IL-11 Protein uniprot:P20809
Egfr Protein uniprot:Q01279
Upf1 Protein uniprot:Q9EPU0
Zmpste24 Protein uniprot:Q80W54
Orc2 Protein uniprot:Q60862
Rbbp4 Protein uniprot:Q60972
Serpine1 Protein uniprot:P05121
TNF Protein uniprot:P01375
Srpk2 Protein uniprot:O54781
CCL2 Protein uniprot:P13500
CXCL1 Protein uniprot:P09341
Cdc42 Protein uniprot:P60766
CXCL8 Protein uniprot:P10145
Pole3 Protein uniprot:Q9JKP7
Rac1 Protein uniprot:P63001
Parp1 Protein uniprot:P11103
Plaur Protein uniprot:P35456
Casp3 Protein uniprot:P05122
Samhd1 Protein uniprot:Q60710
Cacybp Protein uniprot:Q9CXW3
CSF3 Protein uniprot:P09919
Atrx Protein uniprot:Q61687
Orc1 Protein uniprot:Q9Z1N2
IL-6 Protein uniprot:P05231
LIF Protein uniprot:P15018
Dhx9 Protein uniprot:O70133
Plau Protein uniprot:P06869
Npm1 Protein uniprot:Q61937
Nasp Protein uniprot:Q99MD9
Pcna Protein uniprot:P17918
Pura Protein uniprot:P42669
Nucks1 Protein uniprot:Q80XU3
IL-10 Protein uniprot:P22301
Sqstm1 Protein uniprot:Q64337
Map1lc3b Protein uniprot:Q9CQV6
Bcl2 Protein uniprot:P10417
Smad6 Protein uniprot:O35182
Stat1 Protein uniprot:P42225
mTOR Protein uniprot:P42345.1
Smad2 Protein ncbigene:17126
PRKAA1 Protein uniprot:Q13131
PI3KCA Protein ncbigene:5290
Becn1 Protein uniprot:O88597
Stat3 Protein uniprot:P42227
RELA Protein uniprot:Q04206
NFKB1 Protein uniprot:P19838
Map1lc3a Protein uniprot:Q91VR7
Smad7 Protein uniprot:O35253
BECN1 Protein uniprot:Q14457.2
Pik3c3 Protein uniprot:Q6PF93
BCL2 Protein uniprot:P10415.2
Mcm4 Protein ncbigene:17217
Mcm6 Protein uniprot:P97311
GSK3B Protein uniprot:P49841
Mcm2 Protein uniprot:P97310
Tgfb1 Protein uniprot:P04202
P53 Protein uniprot:P04637
Mcm3 Protein uniprot:P25206
Smad3 Protein uniprot:17127
mTOR Protein uniprot:Q9JLN9
Cxcl12 Protein uniprot:P40224
Smad2 Protein uniprot:Q62432
Smad3 Protein uniprot:Q8BUN5
Jak2 Protein uniprot:O60674
Jak1 Protein uniprot:P23458
MAPK1 Protein uniprot:P28482 p38
MAPK3 Protein uniprot:P27361
Akt1 Protein uniprot:P31750
MAPK14 Protein uniprot:Q16539 p38
Snai1 Protein uniprot:Q02085
Col1a1 Protein uniprot:P02452
Snai2 Protein uniprot:P97469
Tjp1 Protein uniprot:P39447
Cdh1 Protein uniprot:P09803
Jak2 Protein uniprot:Q62120
Jak1 Protein uniprot:P52332

References

  1. A comprehensive network map of IL-17A signaling pathway. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, et al. J Cell Commun Signal. 2023 Mar;17(1):209–15. PubMed Europe PMC Scholia