Lac-Phe pathway (WP5239)

Homo sapiens

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Lac-Phe is formed by CNDP2 and exported outside the cell, into the blood circulation by ABCC5. It is linked to food intake and obesity, where it is increased after exercise and suppresses food intake.

Authors

Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

obesity pathway signaling pathway classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
L-phenylalanine Metabolite chebi:58095
(S)-lactate Metabolite chebi:16651
Lac-Phe Metabolite chebi:167456
Lac-Phe Metabolite chebi:167456
ABCC5 GeneProduct uniprot:O15440
CNDP2 Protein uniprot:Q96KP4

References

  1. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601–6. PubMed Europe PMC Scholia
  2. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, et al. Nature. 2022 Jun;606(7915):785–90. PubMed Europe PMC Scholia