Lipid metabolism in senescent cells (WP5149)

Homo sapiens

Description of the affected lipid metabolism in senecent cells.


Martina Summer-Kutmon


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

lipid metabolic pathway cellular senescence pathway


Label Type Compact URI Comment
PUFAs Metabolite chebi:26208
Oxylipin Metabolite chebi:61121
Free PUFAs Metabolite chebi:26208
HRAS GeneProduct ensembl:ENSG00000174775
PLA2G3 GeneProduct ensembl:ENSG00000100078
PTGS2 GeneProduct ensembl:ENSG00000073756
CDKN1A GeneProduct ensembl:ENSG00000124762
SLCO2A1 GeneProduct ensembl:ENSG00000174640
ALOX5 GeneProduct ensembl:ENSG00000012779
TP53 GeneProduct ensembl:ENSG00000141510
PTGS2 GeneProduct ensembl:ENSG00000073756
PLA2G2D GeneProduct ensembl:ENSG00000117215
PLA2G4A GeneProduct ensembl:ENSG00000116711
PLA2G4C GeneProduct ensembl:ENSG00000105499
PLA2G4D GeneProduct ensembl:ENSG00000159337
PLA2G4E GeneProduct ensembl:ENSG00000188089
PLA2G4F GeneProduct ensembl:ENSG00000168907
PLA2G5 GeneProduct ensembl:ENSG00000127472
PLA2G6 GeneProduct ensembl:ENSG00000184381
PLA2G7 GeneProduct ensembl:ENSG00000146070
PLA2G10 GeneProduct ensembl:ENSG00000069764
PLA2G12A GeneProduct ensembl:ENSG00000123739
PLA2G12B GeneProduct ensembl:ENSG00000138308
PLA2G1B GeneProduct ensembl:ENSG00000170890


  1. The metabolic roots of senescence: mechanisms and opportunities for intervention. Wiley CD, Campisi J. Nat Metab. 2021 Oct;3(10):1290–301. PubMed Europe PMC Scholia