Fibrin complement receptor 3 signaling pathway (WP5128)

Mus musculus



Kristina Hanspers and Egon Willighagen


last edited

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Mus musculus



Cell Type Ontology

microglial cell macrophage

Pathway Ontology

classical complement pathway inflammatory response pathway coagulation cascade pathway


Label Type Compact URI Comment
LPS Metabolite chebi:16412
Fibrin Metabolite chebi:5054
Akt1 GeneProduct ensembl:ENSMUSG00000001729
Il6 GeneProduct ensembl:ENSMUSG00000025746
Ikbkb GeneProduct ensembl:ENSMUSG00000031537
Pik3ca GeneProduct ensembl:ENSMUSG00000027665
Plasminogen GeneProduct ensembl:ENSMUSG00000059481
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Syk GeneProduct ensembl:ENSMUSG00000021457
Rel GeneProduct ensembl:ENSMUSG00000020275
Tlr3 GeneProduct ensembl:ENSMUSG00000031639
Cbl-b GeneProduct ensembl:ENSMUSG00000022637
Myd88 GeneProduct ensembl:ENSMUSG00000032508
Ifnb1 GeneProduct ensembl:ENSMUSG00000048806
Rhoa GeneProduct ensembl:ENSMUSG00000007815
Irak1 GeneProduct ensembl:ENSMUSG00000031392
tPa GeneProduct ensembl:ENSMUSG00000031538
Cxcl10 GeneProduct ensembl:ENSMUSG00000034855
Rapl GeneProduct ensembl:ENSMUSG00000026430
Tirap GeneProduct ensembl:ENSMUSG00000032041
Traf6 GeneProduct ensembl:ENSMUSG00000027164
TRIF GeneProduct ensembl:ENSMUSG00000047123
Cd14 GeneProduct ensembl:ENSMUSG00000051439
Dap12 GeneProduct ensembl:ENSMUSG00000030579
FcRg GeneProduct ensembl:ENSMUSG00000058715
Cxcl3 GeneProduct ensembl:ENSMUSG00000029379
Plasmin GeneProduct ensembl:ENSMUSG00000059481
Irak4 GeneProduct ensembl:ENSMUSG00000059883
MD2 GeneProduct ensembl:ENSMUSG00000025779
Lbp GeneProduct ensembl:ENSMUSG00000016024
Tlr4 GeneProduct ensembl:ENSMUSG00000039005
Src GeneProduct ensembl:ENSMUSG00000027646
TRAM GeneProduct ensembl:ENSMUSG00000056130
Irf3 GeneProduct ensembl:ENSMUSG00000003184
Cd11b GeneProduct ensembl:ENSMUSG00000030786
Cd18 GeneProduct ensembl:ENSMUSG00000000290
TRIF GeneProduct ensembl:ENSMUSG00000047123
Myd88 GeneProduct ensembl:ENSMUSG00000032508
Tnf GeneProduct ensembl:ENSMUSG00000024401
Syk GeneProduct ensembl:ENSMUSG00000021457
Irf3 GeneProduct ensembl:ENSMUSG00000003184
Ccl2 GeneProduct ensembl:ENSMUSG00000035385
Chuk GeneProduct ensembl:ENSMUSG00000025199
Ikbkg GeneProduct ensembl:ENSMUSG00000004221
Pik3ca GeneProduct ensembl:ENSMUSG00000027665
Fga GeneProduct ensembl:ENSMUSG00000028001
Irak2 GeneProduct ensembl:ENSMUSG00000060477
Il12b GeneProduct ensembl:ENSMUSG00000004296
Nos2 GeneProduct ensembl:ENSMUSG00000020826
Fgb GeneProduct ensembl:ENSMUSG00000033831
Fgg GeneProduct ensembl:ENSMUSG00000033860
Rela GeneProduct ensembl:ENSMUSG00000024927
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Rel GeneProduct ensembl:ENSMUSG00000020275
Rela GeneProduct ensembl:ENSMUSG00000024927


  1. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Caron E, Hall A. Science. 1998 Nov 27;282(5394):1717–21. PubMed Europe PMC Scholia
  2. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Science. 1998 Dec 11;282(5396):2085–8. PubMed Europe PMC Scholia
  3. Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Stephens L, Ellson C, Hawkins P. Curr Opin Cell Biol. 2002 Apr;14(2):203–13. PubMed Europe PMC Scholia
  4. Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen. Ugarova TP, Lishko VK, Podolnikova NP, Okumura N, Merkulov SM, Yakubenko VP, et al. Biochemistry. 2003 Aug 12;42(31):9365–73. PubMed Europe PMC Scholia
  5. Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, et al. J Clin Invest. 2004 Jun;113(11):1596–606. PubMed Europe PMC Scholia
  6. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, et al. J Exp Med. 2007 Mar 19;204(3):571–82. PubMed Europe PMC Scholia
  7. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. Nature. 2009 Apr 30;458(7242):1191–5. PubMed Europe PMC Scholia
  8. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Nat Immunol. 2010 Aug;11(8):734–42. PubMed Europe PMC Scholia
  9. Integrins limit the Toll. Means TK, Luster AD. Nat Immunol. 2010 Aug;11(8):691–3. PubMed Europe PMC Scholia
  10. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, et al. Nat Commun. 2015 Sep 10;6:8164. PubMed Europe PMC Scholia