Peptidoglycan cytoplasmic synthesis and recycling pathways (WP5060)

Escherichia coli

PG cytoplasmic synthesis and recycling pathways in E. coli


Joe G , Egon Willighagen , and Kristina Hanspers


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Escherichia coli



Pathway Ontology

peptidoglycan biosynthetic pathway


Label Type Compact URI Comment
D-Ala Metabolite pubchem.compound:71080
glutamine Metabolite chebi:28300
L-Ala-gamma-D-Glu-meso-DAP-D-Ala Metabolite pubchem.compound:51351779
D-glucosamine-6-phosphate Metabolite chebi:20995
UDP-MurNAc-L-Ala Metabolite pubchem.compound:5490066
L-glutamate Metabolite chebi:29985
D-Ala-D-Ala Metabolite chebi:16576
Diaminopimelic acid Metabolite hmdb:HMDB01370
L-alanine Metabolite chebi:16977
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Metabolite chebi:28138
UTP Metabolite chebi:46398
D-alanine Metabolite chebi:15570
Undecaprenyl phosphate Metabolite chebi:16141
Glucosamine-1P Metabolite hmdb:HMDB01109
UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala Metabolite pubchem.compound:46173752
UDP-MurNAc-L-Ala-D-Glu Metabolite chebi:16970
Undecaprenyl pyrophosphate Metabolite chebi:17047
Fructose-6-phosphate Metabolite chebi:15946
D-glutamate Metabolite chebi:29986
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP Metabolite chebi:28639
UDP-GlcNAc Metabolite chebi:16264
UDP-MurNAc Metabolite chebi:70765
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala Metabolite chebi:18199
phosphoenolpyruvate Metabolite chebi:58702
UDP-GlcNAc-enolpyruvate Metabolite chebi:68483
NADPH Metabolite hmdb:HMDB00221
N-acetylglucosamine-1-phosphate Metabolite chebi:16446
Peptidoglycan Layer Metabolite chebi:8005
Acetyl-CoA Metabolite hmdb:HMDB01206
L-alanine Metabolite chebi:16977
GlcNAc-6-P Metabolite pubchem.compound:150941
MurNAc 6-phosphate Metabolite chebi:47968
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala Metabolite pubchem.compound:163626
MurNAc Metabolite pubchem.compound:5462244
1,6-anhMurNAc Metabolite chebi:40666
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala Metabolite pubchem.compound:163626
GlcNAc Metabolite chebi:506227
L-Ala-gamma-D-Glu-meso-DAP Metabolite pubchem.compound:51351754
glmS GeneProduct uniprot:P17169
glmU GeneProduct uniprot:P0ACC7
glmM GeneProduct uniprot:P31120
murF GeneProduct uniprot:P11880
glmU GeneProduct uniprot:P0ACC7
murE GeneProduct uniprot:P22188
murD GeneProduct uniprot:P14900
murC GeneProduct uniprot:P17952
murB GeneProduct uniprot:P08373
murA GeneProduct uniprot:P0A749
murG GeneProduct uniprot:P17443
mraY GeneProduct uniprot:P0A6W3
ddlB GeneProduct uniprot:P07862
dadX GeneProduct uniprot:P29012
alr GeneProduct uniprot:P0A6B4
murI GeneProduct uniprot:P22634
ampG GeneProduct uniprot:P0AE16
mpl GeneProduct uniprot:P37773
murJ GeneProduct uniprot:P0AF16
ftsW GeneProduct uniprot:P0ABG4
mtgA GeneProduct uniprot:P46022
murP GeneProduct uniprot:P77272
anmK GeneProduct uniprot:P77570
murQ GeneProduct uniprot:P76535
nagA GeneProduct uniprot:P0AF18
nagB GeneProduct uniprot:P0A759
nagK GeneProduct uniprot:P75959
nagZ GeneProduct uniprot:P75949
Penicillin-binding protein 1C Protein uniprot:P76577
Penicillin-binding protein 1B Protein uniprot:P02919
Undecaprenyl-diphosphatase Protein uniprot:P60932
Penicillin-binding protein 1A Protein uniprot:P02918
Penicillin-binding protein 2(Peptidoglycan D,D-transpeptidase MrdA} Protein uniprot:Q2TL65
Penicillin-binding protein 3(Peptidoglycan D,D-transpeptidase FtsI) Protein uniprot:P0AD68
1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD) Protein uniprot:P13016
Murein tetrapeptide carboxypeptidase (LdcA) Protein uniprot:P76008


  1. Cytoplasmic steps of peptidoglycan biosynthesis. Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D. FEMS Microbiol Rev. 2008 Mar;32(2):168–207. PubMed Europe PMC Scholia
  2. Bacteria’s different ways to recycle their own cell wall. Mayer C, Kluj RM, Mühleck M, Walter A, Unsleber S, Hottmann I, et al. Int J Med Microbiol. 2019 Nov;309(7):151326. PubMed Europe PMC Scholia