Acetogenesis (WP5019)

Acetobacterium woodii

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Acetogenesis from H2 and CO2 in Acetobacterium woodii, based on Figure 3 from Diender et al (2015) [PMID:26635746]. This pathway model shows both proposed theoretical pathways of CO conversion to acetate, as well as the acetogenic metabolism driven by CO co-fermented with formate. Two large complexes are involved in this process (top right corner): 1. the RnF complex (sodium ion transport outside of the cell membrane) 2. the ATPase complex (sodium ion translocation to inner cell membrane).

Authors

Lars Willighagen , Kristina Hanspers , and Denise Slenter

Activity

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Organisms

Communities

Annotations

Pathway Ontology

classic metabolic pathway carbon fixation pathway

Participants

Label Type Compact URI Comment
formate Metabolite chebi:15740
ATP Metabolite chebi:30616
hydron Metabolite chebi:15378
5-Methyltetrahydrofolate Metabolite chebi:15641
HSCoA Metabolite chebi:15346
ADP Metabolite chebi:456216
5,10-Methylenetetrahydrofolate Metabolite chebi:1989
dihydrogen Metabolite chebi:18276
acetate Metabolite chebi:30089
carbon dioxide Metabolite chebi:16526
carbon monooxide Metabolite chebi:17245
methyl Metabolite chebi:32875
5,10-Methenyltetrahydrofolate Metabolite chebi:15638
10-Formyltetrahydrofolate Metabolite chebi:15637
Tetrahydrofolate Metabolite chebi:20506
hydrogenphosphate Metabolite chebi:43474
acetyl-CoA Metabolite chebi:15351
carbon dioxide Metabolite chebi:16526
ATP Metabolite chebi:30616
ADP Metabolite chebi:456216
hydrogenphosphate Metabolite chebi:43474
hydron Metabolite chebi:15378
dihydrogen Metabolite chebi:18276
NADH Metabolite chebi:16908
NAD(1-) Metabolite chebi:57540
Oxidised ferredoxin Metabolite chebi:17908
Reduced ferredoxin Metabolite chebi:17513
dihydrogen Metabolite chebi:18276
acetyl-phosphate Metabolite chebi:15350
MetV Protein uniprot:H6LBX8
RnfG Protein uniprot:H6LC30
FdhF1 Protein uniprot:H6LB59
RnfC Protein uniprot:H6LC32
Fhs1 Protein uniprot:H6LBX4 Formate--tetrahydrofolate ligase
RnfC2 Protein uniprot:H6LBX7
RnfD Protein uniprot:H6LC31
MetF Protein uniprot:H6LBX9
HycB2 Protein uniprot:H6LB62
RnfA Protein uniprot:H6LC28
RnfB Protein uniprot:H6LC27
HycB1 Protein uniprot:H6LB60
RnfE Protein uniprot:H6LC29
HydD Protein uniprot:H6LFG5
AcsA Protein uniprot:H6LD21 CO dehydrogenase
HydA1 Protein uniprot:H6LFG3
HycB3 Protein uniprot:H6LB64
AtpE Protein uniprot:Q9RMB5 Subunit c
HydA2 Protein uniprot:H6LB65
HydB Protein uniprot:H6LFG4
HydC Protein uniprot:H6LFG7
FdhF2 Protein uniprot:H6LB61
HycB3 Protein uniprot:H6LB64
HydA2 Protein uniprot:H6LB65
MetF Protein uniprot:H6LBX9
RnfG Protein uniprot:H6LC30
RnfD Protein uniprot:H6LC31
RnfA Protein uniprot:H6LC28
RnfB Protein uniprot:H6LC27
RnfE Protein uniprot:H6LC29
AtpB Protein uniprot:Q9RMB6 Subunit a
AtpH Protein uniprot:Q9RMB3 Subunit delta
AtpF Protein uniprot:Q9RMB4 Subunit b
AtpD Protein uniprot:P50002 Subunit beta
AtpC Protein uniprot:P50009 Subunit epsilon
AtpG Protein uniprot:P50005 Subunit gamma
AtpA Protein uniprot:P50000 Subunit alpha
FolD Protein uniprot:H6LBX6
FchA Protein uniprot:H6LBX5 Methenyl-THF cyclohydrolase
AcsE Protein uniprot:H6LD20 Methyl-transferase
AcsD Protein uniprot:H6LD18 Small subunit
AcsC Protein uniprot:H6LD19 Large subunit
AcsD Protein uniprot:H6LD18 Small subunit
AcsC Protein uniprot:H6LD19 Large subunit
AcsB1 Protein uniprot:H6LD23 Acetyl-CoA synthase
Pta Protein uniprot:H6LJY6
AckA Protein uniprot:H6LBE7 acetate kinase

References

  1. Pathways and Bioenergetics of Anaerobic Carbon Monoxide Fermentation. Diender M, Stams AJM, Sousa DZ. Front Microbiol. 2015 Nov 19;6:1275. PubMed Europe PMC Scholia