Steroid biosynthesis (WP496)

Homo sapiens

Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP496 CPTAC Assay Portal].

Authors

Andrew Kwa , Martijn Van Iersel , Kristina Hanspers , Alex Pico , Anatolymikutin , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Eric Weitz , and Finterly Hu

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

steroid hormone biosynthetic pathway

Participants

Label Type Compact URI Comment
Dehydroepiandrosterone Metabolite cas:53-43-0
Estradiol Metabolite cas:57-91-0
Progesterone Metabolite cas:57-83-0
Androstenediol Metabolite hmdb:HMDB0005849
Dihydrotestosterone Metabolite hmdb:HMDB0002961
Testosterone Metabolite cas:58-22-0
17-alpha-OH-pregnenolone Metabolite hmdb:HMDB0000363
Estrone Metabolite cas:53-16-7
Pregnenolone Metabolite cas:145-13-1
17-alpha-OH-progesterone Metabolite hmdb:HMDB0000374
Cholesterol Metabolite cas:57-88-5
Androstenedione Metabolite cas:63-05-8
HSD17B4 GeneProduct ncbigene:3295
HSD3B1 GeneProduct ncbigene:3283
Steroid 19-hydroxylase GeneProduct ensembl:ENSG00000120054
HSD17B2 GeneProduct ncbigene:3294
Hydroxyprogesterone aldolase GeneProduct eccode:4.1.2.30
F13B GeneProduct ncbigene:2165
HSD3B2 GeneProduct ncbigene:3284
CYP17A1 GeneProduct ncbigene:1586
HSD17B1 GeneProduct ncbigene:3292
HSD17B3 GeneProduct ncbigene:3293
HSD17B7 GeneProduct ncbigene:51478

References

  1. Diagram of the pathways of human steroidogenesis. Häggström M, Richfield D. Wiki J Med [Internet]. 2014;1(1). Available from: http://dx.doi.org/10.15347/wjm/2014.005 DOI Scholia