Genes controlling nephrogenesis (WP4823)

Homo sapiens

Kidneys develop from intermediate mesoderm under the timed or sequential control of a growing number of genes. These genes have been identified at various stages of glomerulotubular development in the mammalian kidney. The genes listed have been tested in various genetically modified mice, and their location corresponds to the classical stages of kidney development postulated by Saxen in 1987.


Iulia Ioncu , Friederike Ehrhart , and Finterly Hu


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Homo sapiens


Rare Diseases


Pathway Ontology

signaling pathway

Disease Ontology



Label Type Compact URI Comment
ILK GeneProduct ensembl:ENSG00000166333
ETV4 GeneProduct ensembl:ENSG00000175832
SHH GeneProduct ensembl:ENSG00000164690
GLI3 GeneProduct ensembl:ENSG00000106571
LHX1 GeneProduct ensembl:ENSG00000273706 formerly known as LIM-1, LIM1, LIM homeobox 1
CTNNB1 GeneProduct ensembl:ENSG00000168036
HNF1B GeneProduct ensembl:ENSG00000275410
EYA1 GeneProduct ensembl:ENSG00000104313
ITGB1 GeneProduct ensembl:ENSG00000150093
ITGA3 GeneProduct ensembl:ENSG00000005884
LMX1B GeneProduct ensembl:ENSG00000136944
GDNF GeneProduct ensembl:ENSG00000168621
CXCR4 GeneProduct ensembl:ENSG00000121966
SIX1 GeneProduct ensembl:ENSG00000126778
FOXD1 GeneProduct ensembl:ENSG00000251493
PDGFB GeneProduct ensembl:ENSG00000100311
HOXA11 GeneProduct ensembl:ENSG00000005073
CXCL12 GeneProduct ensembl:ENSG00000107562
VEGFA GeneProduct ensembl:ENSG00000112715
KIRREL1 GeneProduct ensembl:ENSG00000183853
LAMB2 GeneProduct ensembl:ENSG00000172037
KDR GeneProduct ensembl:ENSG00000128052
WT1 GeneProduct ensembl:ENSG00000184937
LHX1 GeneProduct ensembl:ENSG00000273706
FOXC2 GeneProduct ensembl:ENSG00000176692
NCK1 GeneProduct ensembl:ENSG00000158092
ITGA8 GeneProduct ensembl:ENSG00000077943
NPHS2 GeneProduct ensembl:ENSG00000116218
NPHS1 GeneProduct ensembl:ENSG00000161270
FGF8 GeneProduct ensembl:ENSG00000107831
RET GeneProduct ensembl:ENSG00000165731
CD2AP GeneProduct ensembl:ENSG00000198087
WNT4 GeneProduct ensembl:ENSG00000162552
ROBO2 GeneProduct ensembl:ENSG00000185008
NCK2 GeneProduct ensembl:ENSG00000071051
ITGB1 GeneProduct ensembl:ENSG00000150093
FOXC1 GeneProduct ensembl:ENSG00000054598
NOTCH2 GeneProduct ensembl:ENSG00000134250
TCF21 GeneProduct ensembl:ENSG00000118526
PDGFRB GeneProduct ensembl:ENSG00000113721
PAX2 GeneProduct ensembl:ENSG00000075891
CD36 GeneProduct ensembl:ENSG00000135218
SLIT2 GeneProduct ensembl:ENSG00000145147
EMX2 GeneProduct ensembl:ENSG00000170370
FGFR2 GeneProduct ensembl:ENSG00000066468
HOXD11 GeneProduct ensembl:ENSG00000128713
HNF1B GeneProduct ensembl:ENSG00000275410
HNF1B GeneProduct ensembl:ENSG00000275410


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