Purine metabolism (WP4792)

Homo sapiens

Overview of purine metabolism; metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels. This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version of this PW including disorders, based on ed. 4, can be found [https://www.wikipathways.org/index.php/Pathway:WP4224 here]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4792 CPTAC Assay Portal]


Denise Slenter , Martina Summer-Kutmon , Lauren J. Dupuis , Finterly Hu , and Egon Willighagen


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Homo sapiens


Inherited Metabolic Disorders (IMD) Pathways Rare Diseases


Pathway Ontology

purine metabolic pathway


Label Type Compact URI Comment
PRPP Metabolite chebi:17111
ATP Metabolite chebi:30616
XMP Metabolite chebi:57464
SAICARP Metabolite chebi:58443
AICA-riboside Metabolite chebi:28498
AMP Metabolite chebi:456215
Xanthosine Metabolite chebi:18107
2'-Deoxyadenosine Metabolite chebi:17256
Inosine Metabolite chebi:17596
GDP Metabolite chebi:58189
Ribose-5-P Metabolite chebi:52742
SAICA-riboside Metabolite chebi:18319
dGDP Metabolite chebi:58595
Succinyladenosine Metabolite chebi:71169
dATP Metabolite chebi:61404
AICARP Metabolite chebi:58475
2,8-Dihydroxyadenine Metabolite wikidata:Q4596812
dADP Metabolite chebi:57667
Adenosine Metabolite chebi:16335
dAMP Metabolite chebi:58245
ITP Metabolite chebi:61402 is a nucleoside triphosphate(4−)
Hypoxanthine Metabolite chebi:17368
Guanosine Metabolite chebi:16750
S-AMP Metabolite chebi:57567 succinyladenosine monophosphate
Xanthine Metabolite chebi:17712
ADP Metabolite chebi:456216
GTP Metabolite chebi:37565
dGTP Metabolite chebi:16497
Urate Metabolite chebi:17775
Adenine Metabolite chebi:16708
Guanine Metabolite chebi:16235
dGMP Metabolite chebi:57673
FAICARP Metabolite chebi:58467
2-Deoxyguanosine Metabolite chebi:17172
GMP Metabolite chebi:58115
2'-deoxyinosine Metabolite chebi:28997
IMP Metabolite chebi:58053
APRT Protein uniprot:P07741
ATIC Protein uniprot:P31939
ADA Protein uniprot:P00813 aka Adenosine deaminase
ADSL Protein uniprot:P30566
PRPS1 Protein uniprot:P60891
ADSS Protein uniprot:P30520 Adenylosuccinate synthetase isozyme 2
ADSL Protein uniprot:P30566
PRPPs Protein eccode:
IMPDH1 Protein uniprot:P20839
HPRT1 Protein uniprot:P00492
DGUOK Protein uniprot:Q16854
AMPD1 Protein uniprot:P23109
PNP Protein uniprot:P00491
ITPA Protein uniprot:Q9BY32
RR Protein eccode: ribonucleotide reductase
PNP Protein uniprot:P00491
PNP Protein uniprot:P00491
XO Protein uniprot:P47989
RR Protein eccode:
ATIC Protein uniprot:P31939
ADA Protein uniprot:P00813
PNP Protein uniprot:P00491
HPRT1 Protein uniprot:P00492
XO Protein uniprot:P47989
PNP Protein uniprot:P00491
XO Protein uniprot:P47989
PNP Protein uniprot:P00491


  1. Combined Immune Deficiencies. Su HC, Lenardo MJ. In: Stiehm’s Immune Deficiencies [Internet]. Elsevier; 2014. p. 143–69. Available from: http://dx.doi.org/10.1016/B978-0-12-405546-9.00005-4 DOI Scholia
  2. Physician’s Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases [Internet]. Blau N, Duran M, Gibson KM, Vici CD. Springer; 2014. 867 p. Available from: https://play.google.com/store/books/details?id=t9i6BQAAQBAJ OpenLibrary Worldcat