HIPK2 in kidney fibrosis (WP4751)

Homo sapiens

This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of [https://pubmed.ncbi.nlm.nih.gov/22406746/ Jin et. al.]


Agustin Gonzalez-Vicente , Kristina Hanspers , and Egon Willighagen


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Homo sapiens


Diseases Renal Genomics Pathways


Disease Ontology

renal fibrosis

Pathway Ontology

kidney disease pathway


Label Type Compact URI Comment
SIAH1 GeneProduct ncbigene:6477
HIPK2 GeneProduct ncbigene:28996


  1. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, et al. Nat Med. 2012 Mar 11;18(4):580–8. PubMed Europe PMC Scholia