HIPK2 in kidney fibrosis (WP4751)

Homo sapiens

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This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of [https://pubmed.ncbi.nlm.nih.gov/22406746/ Jin et. al.]

Authors

Agustin Gonzalez-Vicente , Kristina Hanspers , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Diseases Renal Genomics Pathways

Annotations

Disease Ontology

renal fibrosis

Pathway Ontology

kidney disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
SIAH1 GeneProduct ncbigene:6477
HIPK2 GeneProduct ncbigene:28996

References

  1. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, et al. Nat Med. 2012 Mar 11;18(4):580–8. PubMed Europe PMC Scholia