Aerobic glycolysis (WP4629)

Homo sapiens

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [https://www.wikipathways.org/index.php/Pathway:WP4628] This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [https://www.wikipathways.org/index.php/Pathway:WP534] Referred article: Shestov et al., 2014 [https://www.ncbi.nlm.nih.gov/pubmed/25009227]

Authors

Kelly Janssen , Egon Willighagen , Alex Pico , Denise Slenter , Eric Weitz , Finterly Hu , Kristina Hanspers , and Ash Iyer

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glycolysis/gluconeogenesis pathway gluconeogenesis pathway

Participants

Label Type Compact URI Comment
ATP Metabolite chebi:15422
AMP Metabolite chebi:16027
O2e Metabolite chebi:26689
H Metabolite chebi:49637
2PGA Metabolite hmdb:HMDB0000362
BPG Metabolite hmdb:HMDB0001270
PYR Metabolite hmdb:HMDB0000243
GAP Metabolite hmdb:HMDB0001112
ATP Metabolite chebi:15422
G6P Metabolite chebi:75052 Glucose-6-Phosphate (2-)
LAC Metabolite hmdb:HMDB0000190
PEP Metabolite hmdb:HMDB0000263
3PG Metabolite hmdb:HMDB0000807
H Metabolite chebi:49637
GLU Metabolite hmdb:HMDB0000122
F6P Metabolite chebi:61527
DHAP Metabolite hmdb:HMDB0001473
GLUe Metabolite hmdb:HMDB0000122
ADP Metabolite chebi:16761
FBP Metabolite hmdb:HMDB0001058
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
AMP Metabolite chebi:16027
NAD Metabolite chebi:15846
P Metabolite chebi:28659
NADH Metabolite chebi:16908
H Metabolite chebi:49637
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
LACe Metabolite hmdb:HMDB0000190
NAD Metabolite chebi:15846
NADH Metabolite chebi:16908
ADP Metabolite chebi:16761
P Metabolite chebi:28659
ATP Metabolite chebi:15422
O2 Metabolite chebi:26689
O2 Metabolite chebi:26689
NADH Metabolite chebi:16908
ADP Metabolite chebi:16761
P Metabolite chebi:28659
ATP Metabolite chebi:15422
NAD Metabolite chebi:15846
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
H Metabolite chebi:49637
P Metabolite chebi:28659
ADP Metabolite chebi:16761
ADP Metabolite chebi:16761
PYR Metabolite hmdb:HMDB0000243
NAD Metabolite chebi:15846
P Metabolite chebi:28659
H Metabolite chebi:49637
ATP Metabolite chebi:15422
HK GeneProduct ncbigene:3098
GLUT GeneProduct ncbigene:6513
PGK GeneProduct ncbigene:5230
ENO GeneProduct ncbigene:2023
GPI GeneProduct ncbigene:2821 glucose-6-phosphate isomerase
LDH GeneProduct ncbigene:3939
PK GeneProduct ncbigene:5315
ALD GeneProduct ncbigene:226
PFK GeneProduct ncbigene:5213 Type your comment here
GAPDH GeneProduct ensembl:ENSG00000111640
PGM GeneProduct ncbigene:5224
TPI GeneProduct ncbigene:7167
LACT GeneProduct ncbigene:0 Monocarboxylate transporters (type based on tissue specificity)
AK GeneProduct eccode:2.7.4.3
Enzyme GeneProduct ncbigene:2821 glucose-6-phosphate isomerase

References

  1. Biochemistry, Fifth Edition [Internet]. Berg JM, Tymoczko JL, Stryer L. 2002. 1096 p. Available from: https://books.google.com/books/about/Biochemistry_Fifth_Edition.html?hl=&id=pMxpAAAAMAAJ OpenLibrary Worldcat
  2. Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Carbonell J, Felíu JE, Marco R, Sols A. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
  3. Regulation of mitochondrial oxidative phosphorylation through cell signaling. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW. Biochim Biophys Acta. 2007 Dec;1773(12):1701–20. PubMed Europe PMC Scholia