Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [https://www.wikipathways.org/index.php/Pathway:WP4628] This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [https://www.wikipathways.org/index.php/Pathway:WP534] Referred article: Shestov et al., 2014 [https://www.ncbi.nlm.nih.gov/pubmed/25009227]

Authors

Kelly Janssen , Egon Willighagen , Alex Pico , Denise Slenter , Eric Weitz , and Finterly Hu

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: glycolysis/gluconeogenesis pathway gluconeogenesis pathway

Participants

References

1. Berg JM, Tymoczko JL, Stryer L. Biochemistry, Fifth Edition [Internet]. W. H. Freeman; 2002. 1050 p. Available from: https://books.google.com/books/about/Biochemistry_Fifth_Edition.html?hl=&id=uDFqAAAAMAAJ OpenLibrary Worldcat
2. Carbonell J, Felíu JE, Marco R, Sols A. Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
3. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW. Regulation of mitochondrial oxidative phosphorylation through cell signaling. Biochim Biophys Acta. 2007 Dec;1773(12):1701–20. PubMed Europe PMC Scholia